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Assessment of Fcγ receptor-dependent binding of influenza hemagglutinin vaccine-induced antibodies in a non-human primate model

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Title: Assessment of Fcγ receptor-dependent binding of influenza hemagglutinin vaccine-induced antibodies in a non-human primate model
Authors: Yuji Masuta, Shokichi Takahama, Takuto Nogimori, Saya Moriyama, Yoshimasa Takahashi, Takuya Yamamoto
Source: iScience, Vol 25, Iss 10, Pp 105085- (2022)
Publisher Information: Elsevier, 2022.
Publication Year: 2022
Collection: LCC:Science
Subject Terms: Biological sciences, Immunology, Immunological methods, Science
More Details: Summary: Several cross-protective antibodies that recognize a broad range of influenza A virus (IAV) strains are known to have functions in virus elimination such as Fcγ receptor (FcγR)-effector function and neutralizing activity against the head region. Although few studies have used primary cells as effector cells, the FcγR-effector function was evaluated after isolating each cell subset. Herein, we established an original assay system to evaluate purified FI6 IgG-mediated binding to hemagglutinin (HA)-expressing cells by flow cytometry using peripheral blood mononuclear cells from cynomolgus macaques. In addition, we evaluated the FcγR-effector function of IAV vaccine-induced anti-HA antibodies in cynomolgus macaques after administering the split vaccine. We found several cell types, mainly classical monocytes, bound to HA-expressing target cells in an FcγR-dependent manner, that were dominant in the binding of the cell population. Thus, this assay system could facilitate the development of a universal influenza vaccine.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2589-0042
Relation: http://www.sciencedirect.com/science/article/pii/S2589004222013578; https://doaj.org/toc/2589-0042
DOI: 10.1016/j.isci.2022.105085
Access URL: https://doaj.org/article/d46b953959d045d888ad922f93e1bb2a
Accession Number: edsdoj.46b953959d045d888ad922f93e1bb2a
Database: Directory of Open Access Journals
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  Data: Assessment of Fcγ receptor-dependent binding of influenza hemagglutinin vaccine-induced antibodies in a non-human primate model
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  Data: <searchLink fieldCode="AR" term="%22Yuji+Masuta%22">Yuji Masuta</searchLink><br /><searchLink fieldCode="AR" term="%22Shokichi+Takahama%22">Shokichi Takahama</searchLink><br /><searchLink fieldCode="AR" term="%22Takuto+Nogimori%22">Takuto Nogimori</searchLink><br /><searchLink fieldCode="AR" term="%22Saya+Moriyama%22">Saya Moriyama</searchLink><br /><searchLink fieldCode="AR" term="%22Yoshimasa+Takahashi%22">Yoshimasa Takahashi</searchLink><br /><searchLink fieldCode="AR" term="%22Takuya+Yamamoto%22">Takuya Yamamoto</searchLink>
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  Data: iScience, Vol 25, Iss 10, Pp 105085- (2022)
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  Data: Elsevier, 2022.
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  Data: Summary: Several cross-protective antibodies that recognize a broad range of influenza A virus (IAV) strains are known to have functions in virus elimination such as Fcγ receptor (FcγR)-effector function and neutralizing activity against the head region. Although few studies have used primary cells as effector cells, the FcγR-effector function was evaluated after isolating each cell subset. Herein, we established an original assay system to evaluate purified FI6 IgG-mediated binding to hemagglutinin (HA)-expressing cells by flow cytometry using peripheral blood mononuclear cells from cynomolgus macaques. In addition, we evaluated the FcγR-effector function of IAV vaccine-induced anti-HA antibodies in cynomolgus macaques after administering the split vaccine. We found several cell types, mainly classical monocytes, bound to HA-expressing target cells in an FcγR-dependent manner, that were dominant in the binding of the cell population. Thus, this assay system could facilitate the development of a universal influenza vaccine.
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