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Complications after surgery for benign prostatic enlargement: a population-based cohort study in Ontario, Canada

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Title: Complications after surgery for benign prostatic enlargement: a population-based cohort study in Ontario, Canada
Authors: Rano Matta, Erind Dvorani, Christopher Wallis, Amanda Hird, Joseph LaBossiere, Girish Kulkarni, Ronald Kodama, Lesley Carr, Sidney B Radomski, Refik Saskin, Sender Herschorn, Robert K Nam
Source: BMJ Open, Vol 9, Iss 12 (2019)
Publisher Information: BMJ Publishing Group, 2019.
Publication Year: 2019
Collection: LCC:Medicine
Subject Terms: Medicine
More Details: Objectives To examine the complication rates after benign prostatic enlargement (BPE) surgery and the effects of age, comorbidity and preoperative medical therapy.Design A retrospective, population-based cohort study using linked administrative data.Setting Ontario, Canada.Participants 52 162 men≥66 years undergoing first BPE surgery between 1 January 2003 to 31 December 2014.Intervention Medical therapy preoperatively and surgery for BPE.Primary and secondary outcome measures The primary outcome was overall 30-day postoperative complication rates. Secondary outcomes included BPE-specific event rates (bleeding, infection, obstruction, trauma) and non-BPE specific event rates (cardiovascular, pulmonary, thromboembolic and renal). Multivariable analysis examined the association between preoperative medical therapy and postoperative complication rates.Results The 30-day overall complication rate after BPE surgery was 2828 events/10 000 procedures and increased annually over the study period. Receipt of preoperative α-blocker monotherapy (relative rate (RR) 1.05; 95% CI 1.00 to 1.09; p=0.033) and antithrombotic medications (RR 1.27; 95% CI 1.22 to 1.31; p
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2044-6055
Relation: https://bmjopen.bmj.com/content/9/12/e032170.full; https://doaj.org/toc/2044-6055
DOI: 10.1136/bmjopen-2019-032170
Access URL: https://doaj.org/article/c27ba983ca1c4062b1e180086969e6f1
Accession Number: edsdoj.27ba983ca1c4062b1e180086969e6f1
Database: Directory of Open Access Journals
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  Data: <searchLink fieldCode="AR" term="%22Rano+Matta%22">Rano Matta</searchLink><br /><searchLink fieldCode="AR" term="%22Erind+Dvorani%22">Erind Dvorani</searchLink><br /><searchLink fieldCode="AR" term="%22Christopher+Wallis%22">Christopher Wallis</searchLink><br /><searchLink fieldCode="AR" term="%22Amanda+Hird%22">Amanda Hird</searchLink><br /><searchLink fieldCode="AR" term="%22Joseph+LaBossiere%22">Joseph LaBossiere</searchLink><br /><searchLink fieldCode="AR" term="%22Girish+Kulkarni%22">Girish Kulkarni</searchLink><br /><searchLink fieldCode="AR" term="%22Ronald+Kodama%22">Ronald Kodama</searchLink><br /><searchLink fieldCode="AR" term="%22Lesley+Carr%22">Lesley Carr</searchLink><br /><searchLink fieldCode="AR" term="%22Sidney+B+Radomski%22">Sidney B Radomski</searchLink><br /><searchLink fieldCode="AR" term="%22Refik+Saskin%22">Refik Saskin</searchLink><br /><searchLink fieldCode="AR" term="%22Sender+Herschorn%22">Sender Herschorn</searchLink><br /><searchLink fieldCode="AR" term="%22Robert+K+Nam%22">Robert K Nam</searchLink>
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  Data: BMJ Open, Vol 9, Iss 12 (2019)
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  Data: Objectives To examine the complication rates after benign prostatic enlargement (BPE) surgery and the effects of age, comorbidity and preoperative medical therapy.Design A retrospective, population-based cohort study using linked administrative data.Setting Ontario, Canada.Participants 52 162 men≥66 years undergoing first BPE surgery between 1 January 2003 to 31 December 2014.Intervention Medical therapy preoperatively and surgery for BPE.Primary and secondary outcome measures The primary outcome was overall 30-day postoperative complication rates. Secondary outcomes included BPE-specific event rates (bleeding, infection, obstruction, trauma) and non-BPE specific event rates (cardiovascular, pulmonary, thromboembolic and renal). Multivariable analysis examined the association between preoperative medical therapy and postoperative complication rates.Results The 30-day overall complication rate after BPE surgery was 2828 events/10 000 procedures and increased annually over the study period. Receipt of preoperative α-blocker monotherapy (relative rate (RR) 1.05; 95% CI 1.00 to 1.09; p=0.033) and antithrombotic medications (RR 1.27; 95% CI 1.22 to 1.31; p
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  Data: https://bmjopen.bmj.com/content/9/12/e032170.full; https://doaj.org/toc/2044-6055
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  Data: 10.1136/bmjopen-2019-032170
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