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Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity

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Title: Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity
Authors: Yura Grabovska, Alan Mackay, Patricia O’Hare, Stephen Crosier, Martina Finetti, Edward C. Schwalbe, Jessica C. Pickles, Amy R. Fairchild, Aimee Avery, Julia Cockle, Rebecca Hill, Janet Lindsey, Debbie Hicks, Mark Kristiansen, Jane Chalker, John Anderson, Darren Hargrave, Thomas S. Jacques, Karin Straathof, Simon Bailey, Chris Jones, Steven C. Clifford, Daniel Williamson
Source: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Publisher Information: Nature Portfolio, 2020.
Publication Year: 2020
Collection: LCC:Science
Subject Terms: Science
More Details: Here, using methylCIBERSORT, the authors characterize the tumour-immune microenvironment of paediatric central nervous system (CNS) tumours and its association with tumour type and prognosis. These findings suggest that immuno-methylomic profiling may inform immunotherapy approaches in paediatric patients with CNS tumour.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-020-18070-y
Access URL: https://doaj.org/article/ec15b2c4e08f447294d1c85b886169aa
Accession Number: edsdoj.15b2c4e08f447294d1c85b886169aa
Database: Directory of Open Access Journals
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  Data: Here, using methylCIBERSORT, the authors characterize the tumour-immune microenvironment of paediatric central nervous system (CNS) tumours and its association with tumour type and prognosis. These findings suggest that immuno-methylomic profiling may inform immunotherapy approaches in paediatric patients with CNS tumour.
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