Examining the Role of CD1d and Natural Killer T Cells in the Development of Nephritis in a Genetically Susceptible Lupus Model.
| Title: | Examining the Role of CD1d and Natural Killer T Cells in the Development of Nephritis in a Genetically Susceptible Lupus Model. |
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| Authors: | Jun-Qi Yang, Xiangshu Wen, Hongzhu Liu, Folayan, Gbolahan, Xin Dong, Min Zhou, Van Kaer, Luc, Singh, Ram Raj |
| Source: | Arthritis & Rheumatism; Apr2007, Vol. 56 Issue 4, p1219-1233, 15p, 4 Black and White Photographs, 2 Charts, 5 Graphs |
| Subject Terms: | KILLER cells, IMMUNOCOMPETENT cells, SYSTEMIC lupus erythematosus, AUTOIMMUNE diseases, INTERLEUKIN-4, T cells |
| Abstract: | This article discusses findings of a study, which examined the role of CD1d-reactive invariant natural killer T (iNKT) cells in the development of autoimmune disease in genetically lupus-prone mice. Diverse sets of T helper cells can promote autoantibody production in humans and animals with systemic lupus erythematosus (SLE). NKT cells produce interleukin-4 (IL-4) and it may be comprised of 2 subsets, like CD4+ T cells and double-negative (DN) T cells. |
| Database: | Complementary Index |
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| Header | DbId: edb DbLabel: Complementary Index An: 27579809 RelevancyScore: 833 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 832.907653808594 |
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| Items | – Name: Title Label: Title Group: Ti Data: Examining the Role of CD1d and Natural Killer T Cells in the Development of Nephritis in a Genetically Susceptible Lupus Model. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Jun-Qi+Yang%22">Jun-Qi Yang</searchLink><br /><searchLink fieldCode="AR" term="%22Xiangshu+Wen%22">Xiangshu Wen</searchLink><br /><searchLink fieldCode="AR" term="%22Hongzhu+Liu%22">Hongzhu Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Folayan%2C+Gbolahan%22">Folayan, Gbolahan</searchLink><br /><searchLink fieldCode="AR" term="%22Xin+Dong%22">Xin Dong</searchLink><br /><searchLink fieldCode="AR" term="%22Min+Zhou%22">Min Zhou</searchLink><br /><searchLink fieldCode="AR" term="%22Van+Kaer%2C+Luc%22">Van Kaer, Luc</searchLink><br /><searchLink fieldCode="AR" term="%22Singh%2C+Ram+Raj%22">Singh, Ram Raj</searchLink> – Name: TitleSource Label: Source Group: Src Data: Arthritis & Rheumatism; Apr2007, Vol. 56 Issue 4, p1219-1233, 15p, 4 Black and White Photographs, 2 Charts, 5 Graphs – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22KILLER+cells%22">KILLER cells</searchLink><br /><searchLink fieldCode="DE" term="%22IMMUNOCOMPETENT+cells%22">IMMUNOCOMPETENT cells</searchLink><br /><searchLink fieldCode="DE" term="%22SYSTEMIC+lupus+erythematosus%22">SYSTEMIC lupus erythematosus</searchLink><br /><searchLink fieldCode="DE" term="%22AUTOIMMUNE+diseases%22">AUTOIMMUNE diseases</searchLink><br /><searchLink fieldCode="DE" term="%22INTERLEUKIN-4%22">INTERLEUKIN-4</searchLink><br /><searchLink fieldCode="DE" term="%22T+cells%22">T cells</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: This article discusses findings of a study, which examined the role of CD1d-reactive invariant natural killer T (iNKT) cells in the development of autoimmune disease in genetically lupus-prone mice. Diverse sets of T helper cells can promote autoantibody production in humans and animals with systemic lupus erythematosus (SLE). NKT cells produce interleukin-4 (IL-4) and it may be comprised of 2 subsets, like CD4+ T cells and double-negative (DN) T cells. |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/art.22490 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 1219 Subjects: – SubjectFull: KILLER cells Type: general – SubjectFull: IMMUNOCOMPETENT cells Type: general – SubjectFull: SYSTEMIC lupus erythematosus Type: general – SubjectFull: AUTOIMMUNE diseases Type: general – SubjectFull: INTERLEUKIN-4 Type: general – SubjectFull: T cells Type: general Titles: – TitleFull: Examining the Role of CD1d and Natural Killer T Cells in the Development of Nephritis in a Genetically Susceptible Lupus Model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jun-Qi Yang – PersonEntity: Name: NameFull: Xiangshu Wen – PersonEntity: Name: NameFull: Hongzhu Liu – PersonEntity: Name: NameFull: Folayan, Gbolahan – PersonEntity: Name: NameFull: Xin Dong – PersonEntity: Name: NameFull: Min Zhou – PersonEntity: Name: NameFull: Van Kaer, Luc – PersonEntity: Name: NameFull: Singh, Ram Raj IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 00043591 Numbering: – Type: volume Value: 56 – Type: issue Value: 4 Titles: – TitleFull: Arthritis & Rheumatism Type: main |
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