| Title: |
Examining the Role of CD1d and Natural Killer T Cells in the Development of Nephritis in a Genetically Susceptible Lupus Model. |
| Authors: |
Jun-Qi Yang, Xiangshu Wen, Hongzhu Liu, Folayan, Gbolahan, Xin Dong, Min Zhou, Van Kaer, Luc, Singh, Ram Raj |
| Source: |
Arthritis & Rheumatism; Apr2007, Vol. 56 Issue 4, p1219-1233, 15p, 4 Black and White Photographs, 2 Charts, 5 Graphs |
| Subject Terms: |
KILLER cells, IMMUNOCOMPETENT cells, SYSTEMIC lupus erythematosus, AUTOIMMUNE diseases, INTERLEUKIN-4, T cells |
| Abstract: |
This article discusses findings of a study, which examined the role of CD1d-reactive invariant natural killer T (iNKT) cells in the development of autoimmune disease in genetically lupus-prone mice. Diverse sets of T helper cells can promote autoantibody production in humans and animals with systemic lupus erythematosus (SLE). NKT cells produce interleukin-4 (IL-4) and it may be comprised of 2 subsets, like CD4+ T cells and double-negative (DN) T cells. |
| Database: |
Complementary Index |
