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Pneumocystis jirovecii with high probability detected in bronchoalveolar lavage fluid of chemotherapy-related interstitial pneumonia in patients with lymphoma using metagenomic next-generation sequencing technology.

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Title: Pneumocystis jirovecii with high probability detected in bronchoalveolar lavage fluid of chemotherapy-related interstitial pneumonia in patients with lymphoma using metagenomic next-generation sequencing technology.
Authors: Jin, Dian, Le, Jing, Yang, Qianqian, Cai, Qianqian, Dai, Hui, Luo, Liufei, Tong, Jiaqi, Shu, Wenxiu
Source: Infectious Agents & Cancer; 12/6/2023, Vol. 18 Issue 1, p1-11, 11p
Subject Terms: LYMPHOMA diagnosis, CYTOMEGALOVIRUSES, BRONCHOALVEOLAR lavage, SEQUENCE analysis, PNEUMOCYSTIS pneumonia, CANCER chemotherapy, INTERSTITIAL lung diseases, RETROSPECTIVE studies, GENOMES, MICROBIOLOGICAL techniques, EPSTEIN-Barr virus, CHI-squared test, DESCRIPTIVE statistics
Abstract: Background: Previous studies achieved low microbial detection rates in lymphoma patients with interstitial pneumonia (IP) after chemotherapy. However, the metagenomic next-generation sequencing (mNGS) is a comprehensive approach that is expected to improve the pathogen identification rate. Thus far, reports on the use of mNGS in lymphoma patients with chemotherapy-related IP remain scarce. In this study, we summarized the microbial detection outcomes of lymphoma patients with chemotherapy-related IP through mNGS testing of bronchoalveolar lavage fluid (BALF). Methods: Fifteen lymphoma patients with chemotherapy-related IP were tested for traditional laboratory microbiology, along with the mNGS of BALF. Then, the results of mNGS and traditional laboratory microbiology were compared. Results: Of the 15 enrolled patients, 11 received rituximab and 8 were administered doxorubicin hydrochloride liposome. The overall microbial yield was 93.3% (14/15) for mNGS versus 13.3% (2/15) for traditional culture methods (P ≤ 0.05). The most frequently detected pathogens were Pneumocystis jirovecii (12/15, 80%), Cytomegalovirus (4/15, 26.7%), and Epstein-Barr virus (3/15, 20%). Mixed infections were detected in 10 cases. Five patients recovered after the treatment with antibiotics alone without glucocorticoids. Conclusion: Our findings obtained through mNGS testing of BALF suggested a high microbial detection rate in lymphoma patients with IP after chemotherapy. Notably, there was an especially high detection rate of Pneumocystis jirovecii. The application of mNGS in patients with chemotherapy-related IP was more sensitive. [ABSTRACT FROM AUTHOR]
Copyright of Infectious Agents & Cancer is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Pneumocystis jirovecii with high probability detected in bronchoalveolar lavage fluid of chemotherapy-related interstitial pneumonia in patients with lymphoma using metagenomic next-generation sequencing technology.
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  Data: <searchLink fieldCode="AR" term="%22Jin%2C+Dian%22">Jin, Dian</searchLink><br /><searchLink fieldCode="AR" term="%22Le%2C+Jing%22">Le, Jing</searchLink><br /><searchLink fieldCode="AR" term="%22Yang%2C+Qianqian%22">Yang, Qianqian</searchLink><br /><searchLink fieldCode="AR" term="%22Cai%2C+Qianqian%22">Cai, Qianqian</searchLink><br /><searchLink fieldCode="AR" term="%22Dai%2C+Hui%22">Dai, Hui</searchLink><br /><searchLink fieldCode="AR" term="%22Luo%2C+Liufei%22">Luo, Liufei</searchLink><br /><searchLink fieldCode="AR" term="%22Tong%2C+Jiaqi%22">Tong, Jiaqi</searchLink><br /><searchLink fieldCode="AR" term="%22Shu%2C+Wenxiu%22">Shu, Wenxiu</searchLink>
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  Data: Infectious Agents & Cancer; 12/6/2023, Vol. 18 Issue 1, p1-11, 11p
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  Data: <searchLink fieldCode="DE" term="%22LYMPHOMA+diagnosis%22">LYMPHOMA diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22CYTOMEGALOVIRUSES%22">CYTOMEGALOVIRUSES</searchLink><br /><searchLink fieldCode="DE" term="%22BRONCHOALVEOLAR+lavage%22">BRONCHOALVEOLAR lavage</searchLink><br /><searchLink fieldCode="DE" term="%22SEQUENCE+analysis%22">SEQUENCE analysis</searchLink><br /><searchLink fieldCode="DE" term="%22PNEUMOCYSTIS+pneumonia%22">PNEUMOCYSTIS pneumonia</searchLink><br /><searchLink fieldCode="DE" term="%22CANCER+chemotherapy%22">CANCER chemotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22INTERSTITIAL+lung+diseases%22">INTERSTITIAL lung diseases</searchLink><br /><searchLink fieldCode="DE" term="%22RETROSPECTIVE+studies%22">RETROSPECTIVE studies</searchLink><br /><searchLink fieldCode="DE" term="%22GENOMES%22">GENOMES</searchLink><br /><searchLink fieldCode="DE" term="%22MICROBIOLOGICAL+techniques%22">MICROBIOLOGICAL techniques</searchLink><br /><searchLink fieldCode="DE" term="%22EPSTEIN-Barr+virus%22">EPSTEIN-Barr virus</searchLink><br /><searchLink fieldCode="DE" term="%22CHI-squared+test%22">CHI-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22DESCRIPTIVE+statistics%22">DESCRIPTIVE statistics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Previous studies achieved low microbial detection rates in lymphoma patients with interstitial pneumonia (IP) after chemotherapy. However, the metagenomic next-generation sequencing (mNGS) is a comprehensive approach that is expected to improve the pathogen identification rate. Thus far, reports on the use of mNGS in lymphoma patients with chemotherapy-related IP remain scarce. In this study, we summarized the microbial detection outcomes of lymphoma patients with chemotherapy-related IP through mNGS testing of bronchoalveolar lavage fluid (BALF). Methods: Fifteen lymphoma patients with chemotherapy-related IP were tested for traditional laboratory microbiology, along with the mNGS of BALF. Then, the results of mNGS and traditional laboratory microbiology were compared. Results: Of the 15 enrolled patients, 11 received rituximab and 8 were administered doxorubicin hydrochloride liposome. The overall microbial yield was 93.3% (14/15) for mNGS versus 13.3% (2/15) for traditional culture methods (P ≤ 0.05). The most frequently detected pathogens were Pneumocystis jirovecii (12/15, 80%), Cytomegalovirus (4/15, 26.7%), and Epstein-Barr virus (3/15, 20%). Mixed infections were detected in 10 cases. Five patients recovered after the treatment with antibiotics alone without glucocorticoids. Conclusion: Our findings obtained through mNGS testing of BALF suggested a high microbial detection rate in lymphoma patients with IP after chemotherapy. Notably, there was an especially high detection rate of Pneumocystis jirovecii. The application of mNGS in patients with chemotherapy-related IP was more sensitive. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Infectious Agents & Cancer is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1186/s13027-023-00556-1
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      – Code: eng
        Text: English
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        PageCount: 11
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    Subjects:
      – SubjectFull: LYMPHOMA diagnosis
        Type: general
      – SubjectFull: CYTOMEGALOVIRUSES
        Type: general
      – SubjectFull: BRONCHOALVEOLAR lavage
        Type: general
      – SubjectFull: SEQUENCE analysis
        Type: general
      – SubjectFull: PNEUMOCYSTIS pneumonia
        Type: general
      – SubjectFull: CANCER chemotherapy
        Type: general
      – SubjectFull: INTERSTITIAL lung diseases
        Type: general
      – SubjectFull: RETROSPECTIVE studies
        Type: general
      – SubjectFull: GENOMES
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      – SubjectFull: MICROBIOLOGICAL techniques
        Type: general
      – SubjectFull: EPSTEIN-Barr virus
        Type: general
      – SubjectFull: CHI-squared test
        Type: general
      – SubjectFull: DESCRIPTIVE statistics
        Type: general
    Titles:
      – TitleFull: Pneumocystis jirovecii with high probability detected in bronchoalveolar lavage fluid of chemotherapy-related interstitial pneumonia in patients with lymphoma using metagenomic next-generation sequencing technology.
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            NameFull: Jin, Dian
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            – D: 06
              M: 12
              Text: 12/6/2023
              Type: published
              Y: 2023
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