Natural antisense transcription of presenilin in sea urchin reveals a possible role for natural antisense transcription in the general control of gene expression during development.
| Title: | Natural antisense transcription of presenilin in sea urchin reveals a possible role for natural antisense transcription in the general control of gene expression during development. |
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| Authors: | Bronchain, Odile, Ducos, Bertrand, Putzer, Harald, Delagrange, Marine, Laalami, Soumaya, Philippe-Caraty, Laetitia, Saroul, Krystel, Ciapa, Brigitte |
| Source: | Journal of Cell Science; Jul2023, Vol. 136 Issue 14, p1-11, 11p |
| Subject Terms: | SEA urchins, GENE expression, GENE regulatory networks, ALZHEIMER'S disease, IN situ hybridization |
| Abstract: | One presenilin gene (PSEN) is expressed in the sea urchin embryo, in the vegetal pole of the gastrula and then mainly in cilia cells located around the digestive system of the pluteus, as we recently have reported. PSEN expression must be accurately regulated for correct execution of these two steps of development. While investigating PSEN expression changes in embryos after expansion of endoderm with LiCl or of ectoderm with Zn2+ by whole-mount in situ hybridization (WISH) and quantitative PCR (qPCR), we detected natural antisense transcription of PSEN. We then found that Endo16 and Wnt5, markers of endo-mesoderm, and of Hnf6 and Gsc, markers of ectoderm, are also sense and antisense transcribed. We discuss that general gene expression could depend on both sense and antisense transcription. This mechanism, together with the PSEN gene, should be included in gene regulatory networks (GRNs) that theorize diverse processes in this species. We suggest that it would also be relevant to investigate natural antisense transcription of PSEN in the field of Alzheimer's disease (AD) where the role of human PSEN1 and PSEN2 is well known. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Natural antisense transcription of presenilin in sea urchin reveals a possible role for natural antisense transcription in the general control of gene expression during development. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bronchain%2C+Odile%22">Bronchain, Odile</searchLink><br /><searchLink fieldCode="AR" term="%22Ducos%2C+Bertrand%22">Ducos, Bertrand</searchLink><br /><searchLink fieldCode="AR" term="%22Putzer%2C+Harald%22">Putzer, Harald</searchLink><br /><searchLink fieldCode="AR" term="%22Delagrange%2C+Marine%22">Delagrange, Marine</searchLink><br /><searchLink fieldCode="AR" term="%22Laalami%2C+Soumaya%22">Laalami, Soumaya</searchLink><br /><searchLink fieldCode="AR" term="%22Philippe-Caraty%2C+Laetitia%22">Philippe-Caraty, Laetitia</searchLink><br /><searchLink fieldCode="AR" term="%22Saroul%2C+Krystel%22">Saroul, Krystel</searchLink><br /><searchLink fieldCode="AR" term="%22Ciapa%2C+Brigitte%22">Ciapa, Brigitte</searchLink> – Name: TitleSource Label: Source Group: Src Data: Journal of Cell Science; Jul2023, Vol. 136 Issue 14, p1-11, 11p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22SEA+urchins%22">SEA urchins</searchLink><br /><searchLink fieldCode="DE" term="%22GENE+expression%22">GENE expression</searchLink><br /><searchLink fieldCode="DE" term="%22GENE+regulatory+networks%22">GENE regulatory networks</searchLink><br /><searchLink fieldCode="DE" term="%22ALZHEIMER'S+disease%22">ALZHEIMER'S disease</searchLink><br /><searchLink fieldCode="DE" term="%22IN+situ+hybridization%22">IN situ hybridization</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: One presenilin gene (PSEN) is expressed in the sea urchin embryo, in the vegetal pole of the gastrula and then mainly in cilia cells located around the digestive system of the pluteus, as we recently have reported. PSEN expression must be accurately regulated for correct execution of these two steps of development. While investigating PSEN expression changes in embryos after expansion of endoderm with LiCl or of ectoderm with Zn<superscript>2+</superscript> by whole-mount in situ hybridization (WISH) and quantitative PCR (qPCR), we detected natural antisense transcription of PSEN. We then found that Endo16 and Wnt5, markers of endo-mesoderm, and of Hnf6 and Gsc, markers of ectoderm, are also sense and antisense transcribed. We discuss that general gene expression could depend on both sense and antisense transcription. This mechanism, together with the PSEN gene, should be included in gene regulatory networks (GRNs) that theorize diverse processes in this species. We suggest that it would also be relevant to investigate natural antisense transcription of PSEN in the field of Alzheimer's disease (AD) where the role of human PSEN1 and PSEN2 is well known. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of Journal of Cell Science is the property of Company of Biologists Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1242/jcs.261284 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1 Subjects: – SubjectFull: SEA urchins Type: general – SubjectFull: GENE expression Type: general – SubjectFull: GENE regulatory networks Type: general – SubjectFull: ALZHEIMER'S disease Type: general – SubjectFull: IN situ hybridization Type: general Titles: – TitleFull: Natural antisense transcription of presenilin in sea urchin reveals a possible role for natural antisense transcription in the general control of gene expression during development. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bronchain, Odile – PersonEntity: Name: NameFull: Ducos, Bertrand – PersonEntity: Name: NameFull: Putzer, Harald – PersonEntity: Name: NameFull: Delagrange, Marine – PersonEntity: Name: NameFull: Laalami, Soumaya – PersonEntity: Name: NameFull: Philippe-Caraty, Laetitia – PersonEntity: Name: NameFull: Saroul, Krystel – PersonEntity: Name: NameFull: Ciapa, Brigitte IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 07 Text: Jul2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 00219533 Numbering: – Type: volume Value: 136 – Type: issue Value: 14 Titles: – TitleFull: Journal of Cell Science Type: main |
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