Bibliographic Details
| Title: |
Natural antisense transcription of presenilin in sea urchin reveals a possible role for natural antisense transcription in the general control of gene expression during development. |
| Authors: |
Bronchain, Odile, Ducos, Bertrand, Putzer, Harald, Delagrange, Marine, Laalami, Soumaya, Philippe-Caraty, Laetitia, Saroul, Krystel, Ciapa, Brigitte |
| Source: |
Journal of Cell Science; Jul2023, Vol. 136 Issue 14, p1-11, 11p |
| Subject Terms: |
SEA urchins, GENE expression, GENE regulatory networks, ALZHEIMER'S disease, IN situ hybridization |
| Abstract: |
One presenilin gene (PSEN) is expressed in the sea urchin embryo, in the vegetal pole of the gastrula and then mainly in cilia cells located around the digestive system of the pluteus, as we recently have reported. PSEN expression must be accurately regulated for correct execution of these two steps of development. While investigating PSEN expression changes in embryos after expansion of endoderm with LiCl or of ectoderm with Zn2+ by whole-mount in situ hybridization (WISH) and quantitative PCR (qPCR), we detected natural antisense transcription of PSEN. We then found that Endo16 and Wnt5, markers of endo-mesoderm, and of Hnf6 and Gsc, markers of ectoderm, are also sense and antisense transcribed. We discuss that general gene expression could depend on both sense and antisense transcription. This mechanism, together with the PSEN gene, should be included in gene regulatory networks (GRNs) that theorize diverse processes in this species. We suggest that it would also be relevant to investigate natural antisense transcription of PSEN in the field of Alzheimer's disease (AD) where the role of human PSEN1 and PSEN2 is well known. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
