| Title: |
The one-pot synthesis of some bioactive pyranopyrazoles and evaluation of their protective behavior against extracellular H2O2 and SNP in T. Thermophila. |
| Authors: |
Addoum, Boutaina, khalfi, Bouchra El, Derdak, Reda, Sakoui, Souraya, Elmakssoudi, Abdelhakim, Soukri, Abdelaziz |
| Source: |
Jordan Journal of Biological Sciences; 2021, Vol. 14 Issue 1, p31-39, 9p |
| Subject Terms: |
BEHAVIORAL assessment, CHEMICAL synthesis, EUKARYOTIC cells, QUINAZOLINONES, VITAMIN C, OXIDATIVE stress |
| Abstract: |
This study aims to evaluate the antioxidant activity of pyranopyrazoles derivatives synthesized via multicomponent reaction and characterized by spectroscopic techniques (¹H-NMR; 13C-NMR and IR). All the synthesized compounds were screened for their anti-stress properties in vivo by using as a test organism the eukaryotic cells "Tetrahymena" exposed to oxidative and nitrosative stress. Thereafter the antioxidant activity in vitro is performed by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assays. Our results clearly showed the protective behavior of the compounds studied (5a and 5b), especially against H2O2-induced stress. On the other hand, the in vitro bioassays reveal that the 5a derivative possesses significant antioxidant activity much greater than ascorbic acid (Vitamin C). All these findings confirmed the prominent antioxidant behavior of the synthesized compounds 5a and 5b. However, further studies are needed to describe the mechanism action and the effect of substitution on the activity of these compounds. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
