The one-pot synthesis of some bioactive pyranopyrazoles and evaluation of their protective behavior against extracellular H2O2 and SNP in T. Thermophila.
| Title: | The one-pot synthesis of some bioactive pyranopyrazoles and evaluation of their protective behavior against extracellular H |
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| Authors: | Addoum, Boutaina, khalfi, Bouchra El, Derdak, Reda, Sakoui, Souraya, Elmakssoudi, Abdelhakim, Soukri, Abdelaziz |
| Source: | Jordan Journal of Biological Sciences; 2021, Vol. 14 Issue 1, p31-39, 9p |
| Subject Terms: | BEHAVIORAL assessment, CHEMICAL synthesis, EUKARYOTIC cells, QUINAZOLINONES, VITAMIN C, OXIDATIVE stress |
| Abstract: | This study aims to evaluate the antioxidant activity of pyranopyrazoles derivatives synthesized via multicomponent reaction and characterized by spectroscopic techniques (¹H-NMR; 13C-NMR and IR). All the synthesized compounds were screened for their anti-stress properties in vivo by using as a test organism the eukaryotic cells "Tetrahymena" exposed to oxidative and nitrosative stress. Thereafter the antioxidant activity in vitro is performed by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assays. Our results clearly showed the protective behavior of the compounds studied (5a and 5b), especially against H |
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| Database: | Complementary Index |
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