EBV-Positive Nodal T- and NK-Cell Lymphoma Mimicking Anaplastic Large Cell Lymphoma: A Case Report.
| Title: | EBV-Positive Nodal T- and NK-Cell Lymphoma Mimicking Anaplastic Large Cell Lymphoma: A Case Report. |
|---|---|
| Authors: | Abro, Brooj1 (AUTHOR), Allen, Pamela2 (AUTHOR), Asakrah, Saja1 (AUTHOR), Bradley, Kyle1 (AUTHOR), Zhang, Linsheng1 (AUTHOR) linsheng.zhang@emory.edu |
| Source: | Hematology Reports. Jun2024, Vol. 16 Issue 2, p308-316. 9p. |
| Subject Terms: | *ANAPLASTIC large-cell lymphoma, *T-cell lymphoma, *HEMATOLOGIC malignancies, *DIFFUSE large B-cell lymphomas, *LYMPHOID tissue, *ANAPLASTIC thyroid cancer |
| Abstract: | EBV-positive nodal T- and NK-cell lymphoma (EBV+ NT/NKCL) is a recently recognized entity in the 5th edition of the WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. Notably, CD30 positivity is frequently observed in (EBV+ NT/NKCL), creating diagnostic challenges to distinguish it from ALK-negative anaplastic large cell lymphoma (ALCL). Furthermore, cases of EBV+ ALCL have been documented in the literature, predating the inclusion of EBV+ nodal cytotoxic T-cell lymphoma as a variant of peripheral T-cell lymphoma. We present a case of a 47-year-old male presenting with multiple lymphadenopathies. The histomorphologic and immunophenotypic features of the lymph node closely resemble ALK-negative ALCL, characterized by uniform CD30 expression and a subcapsular distribution of lymphoma cells. However, the lymphoma cells exhibit diffuse positivity for EBV, consistent with EBV+ NT/NKCL. A case of ALK-negative ALCL with an immunophenotype identical to the EBV-positive case is included for comparison. Given that EBV+ NT/NKCL represents an aggressive neoplasm requiring unique clinical management compared to ALK-negative ALCL, it is critical to accurately differentiate EBV+ NT/NKCL from ALK-negative ALCL with a cytotoxic T-cell immunophenotype. [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: EBV-Positive Nodal T- and NK-Cell Lymphoma Mimicking Anaplastic Large Cell Lymphoma: A Case Report. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Abro%2C+Brooj%22">Abro, Brooj</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Allen%2C+Pamela%22">Allen, Pamela</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Asakrah%2C+Saja%22">Asakrah, Saja</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bradley%2C+Kyle%22">Bradley, Kyle</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Linsheng%22">Zhang, Linsheng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> linsheng.zhang@emory.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Hematology+Reports%22">Hematology Reports</searchLink>. Jun2024, Vol. 16 Issue 2, p308-316. 9p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22ANAPLASTIC+large-cell+lymphoma%22">ANAPLASTIC large-cell lymphoma</searchLink><br />*<searchLink fieldCode="DE" term="%22T-cell+lymphoma%22">T-cell lymphoma</searchLink><br />*<searchLink fieldCode="DE" term="%22HEMATOLOGIC+malignancies%22">HEMATOLOGIC malignancies</searchLink><br />*<searchLink fieldCode="DE" term="%22DIFFUSE+large+B-cell+lymphomas%22">DIFFUSE large B-cell lymphomas</searchLink><br />*<searchLink fieldCode="DE" term="%22LYMPHOID+tissue%22">LYMPHOID tissue</searchLink><br />*<searchLink fieldCode="DE" term="%22ANAPLASTIC+thyroid+cancer%22">ANAPLASTIC thyroid cancer</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: EBV-positive nodal T- and NK-cell lymphoma (EBV+ NT/NKCL) is a recently recognized entity in the 5th edition of the WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. Notably, CD30 positivity is frequently observed in (EBV+ NT/NKCL), creating diagnostic challenges to distinguish it from ALK-negative anaplastic large cell lymphoma (ALCL). Furthermore, cases of EBV+ ALCL have been documented in the literature, predating the inclusion of EBV+ nodal cytotoxic T-cell lymphoma as a variant of peripheral T-cell lymphoma. We present a case of a 47-year-old male presenting with multiple lymphadenopathies. The histomorphologic and immunophenotypic features of the lymph node closely resemble ALK-negative ALCL, characterized by uniform CD30 expression and a subcapsular distribution of lymphoma cells. However, the lymphoma cells exhibit diffuse positivity for EBV, consistent with EBV+ NT/NKCL. A case of ALK-negative ALCL with an immunophenotype identical to the EBV-positive case is included for comparison. Given that EBV+ NT/NKCL represents an aggressive neoplasm requiring unique clinical management compared to ALK-negative ALCL, it is critical to accurately differentiate EBV+ NT/NKCL from ALK-negative ALCL with a cytotoxic T-cell immunophenotype. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Hematology Reports is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/hematolrep16020031 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 308 Subjects: – SubjectFull: ANAPLASTIC large-cell lymphoma Type: general – SubjectFull: T-cell lymphoma Type: general – SubjectFull: HEMATOLOGIC malignancies Type: general – SubjectFull: DIFFUSE large B-cell lymphomas Type: general – SubjectFull: LYMPHOID tissue Type: general – SubjectFull: ANAPLASTIC thyroid cancer Type: general Titles: – TitleFull: EBV-Positive Nodal T- and NK-Cell Lymphoma Mimicking Anaplastic Large Cell Lymphoma: A Case Report. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Abro, Brooj – PersonEntity: Name: NameFull: Allen, Pamela – PersonEntity: Name: NameFull: Asakrah, Saja – PersonEntity: Name: NameFull: Bradley, Kyle – PersonEntity: Name: NameFull: Zhang, Linsheng IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 20388322 Numbering: – Type: volume Value: 16 – Type: issue Value: 2 Titles: – TitleFull: Hematology Reports Type: main |
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