Bibliographic Details
| Title: |
EBV-Positive Nodal T- and NK-Cell Lymphoma Mimicking Anaplastic Large Cell Lymphoma: A Case Report. |
| Authors: |
Abro, Brooj1 (AUTHOR), Allen, Pamela2 (AUTHOR), Asakrah, Saja1 (AUTHOR), Bradley, Kyle1 (AUTHOR), Zhang, Linsheng1 (AUTHOR) linsheng.zhang@emory.edu |
| Source: |
Hematology Reports. Jun2024, Vol. 16 Issue 2, p308-316. 9p. |
| Subject Terms: |
*ANAPLASTIC large-cell lymphoma, *T-cell lymphoma, *HEMATOLOGIC malignancies, *DIFFUSE large B-cell lymphomas, *LYMPHOID tissue, *ANAPLASTIC thyroid cancer |
| Abstract: |
EBV-positive nodal T- and NK-cell lymphoma (EBV+ NT/NKCL) is a recently recognized entity in the 5th edition of the WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. Notably, CD30 positivity is frequently observed in (EBV+ NT/NKCL), creating diagnostic challenges to distinguish it from ALK-negative anaplastic large cell lymphoma (ALCL). Furthermore, cases of EBV+ ALCL have been documented in the literature, predating the inclusion of EBV+ nodal cytotoxic T-cell lymphoma as a variant of peripheral T-cell lymphoma. We present a case of a 47-year-old male presenting with multiple lymphadenopathies. The histomorphologic and immunophenotypic features of the lymph node closely resemble ALK-negative ALCL, characterized by uniform CD30 expression and a subcapsular distribution of lymphoma cells. However, the lymphoma cells exhibit diffuse positivity for EBV, consistent with EBV+ NT/NKCL. A case of ALK-negative ALCL with an immunophenotype identical to the EBV-positive case is included for comparison. Given that EBV+ NT/NKCL represents an aggressive neoplasm requiring unique clinical management compared to ALK-negative ALCL, it is critical to accurately differentiate EBV+ NT/NKCL from ALK-negative ALCL with a cytotoxic T-cell immunophenotype. [ABSTRACT FROM AUTHOR] |
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