| Title: |
Prognostic Role of Serum Sialyl Lewis[sup x] (CD15s) in Colorectal Cancer. |
| Authors: |
Paganuzzi, Michela1, Bobbio, Barbara1, Marroni, Paola1, Filiberti, Rosa2, Secco, Giovanni Battista3, Grossi, Carlo Enrico4 |
| Source: |
Oncology. 2003, Vol. 65 Issue 1, p52-59. 8p. 2 Black and White Photographs, 2 Charts, 1 Graph. |
| Subject Terms: |
*COLON cancer, *GANGLIOSIDES, *CHROMATOGRAPHIC analysis, *GLYCOPROTEINS, *METASTASIS |
| Abstract: |
Objective: Sialyl Lewis[sup x] (sLe[sup x] ) is one ligand for E selectin (CD62E), a glycoprotein that is expressed on activated endothelial cells. Adhesion mediated by endothelial E selectin and sLe[sup x] expressed on human tumor cells could be relevant for the development of metastases. The aim of this study was to investigate whether or not a correlation exists between pre-operative levels of ganglioside serum sLe[sup x] and disease-free interval and survival in colorectal cancer patients. Patients and Methods: Thirty Duke’s B and 52 Duke’s C patients undergoing resection for colorectal cancer were studied. The median follow-up time was 34.8 months. A pool of 57 sera from normal subjects was used as an Internal Normal Standard (INS). sLe[sup x] analyses were performed by a thin layer chromatography (TLC) immunostaining technique. Results were expressed as the ratio (R) between bands of INS and bands from each neoplastic serum. Results: The median R value was 0.80 in normal subjects, 0.70 in Duke’s B patients and 1.0 in Duke’s C patients. No significant differences were detected between sLe[sup x] concentrations in sera from normal and neoplastic subjects (p = 0.1). Using an arbitrary cutoff of R = 0.9, the mean disease-free interval in the whole series was 47.4 months for R <0.9 and 126.0 months for R ≥ 0.9 (p = 0.04). The survival time was 76.8 months for patients with R values <0.9 and 156.3 months for patients with R values ≥0.9 (p = 0.1). Conclusions: High serum levels of ganglioside sLe[sup x] significantly correlate with a favorable prognosis and with a lower occurrence of metastases. It is conceivable that soluble sLe[sup x] may compete with membrane-bound sLe[sup x] in the course of interactions between activated endothelium and tumor cells that have reached the circulation.Copyright © 2003 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
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