Prognostic Role of Serum Sialyl Lewis[sup x] (CD15s) in Colorectal Cancer.
| Title: | Prognostic Role of Serum Sialyl Lewis[sup x] (CD15s) in Colorectal Cancer. |
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| Authors: | Paganuzzi, Michela1, Bobbio, Barbara1, Marroni, Paola1, Filiberti, Rosa2, Secco, Giovanni Battista3, Grossi, Carlo Enrico4 |
| Source: | Oncology. 2003, Vol. 65 Issue 1, p52-59. 8p. 2 Black and White Photographs, 2 Charts, 1 Graph. |
| Subject Terms: | *COLON cancer, *GANGLIOSIDES, *CHROMATOGRAPHIC analysis, *GLYCOPROTEINS, *METASTASIS |
| Abstract: | Objective: Sialyl Lewis[sup x] (sLe[sup x] ) is one ligand for E selectin (CD62E), a glycoprotein that is expressed on activated endothelial cells. Adhesion mediated by endothelial E selectin and sLe[sup x] expressed on human tumor cells could be relevant for the development of metastases. The aim of this study was to investigate whether or not a correlation exists between pre-operative levels of ganglioside serum sLe[sup x] and disease-free interval and survival in colorectal cancer patients. Patients and Methods: Thirty Duke’s B and 52 Duke’s C patients undergoing resection for colorectal cancer were studied. The median follow-up time was 34.8 months. A pool of 57 sera from normal subjects was used as an Internal Normal Standard (INS). sLe[sup x] analyses were performed by a thin layer chromatography (TLC) immunostaining technique. Results were expressed as the ratio (R) between bands of INS and bands from each neoplastic serum. Results: The median R value was 0.80 in normal subjects, 0.70 in Duke’s B patients and 1.0 in Duke’s C patients. No significant differences were detected between sLe[sup x] concentrations in sera from normal and neoplastic subjects (p = 0.1). Using an arbitrary cutoff of R = 0.9, the mean disease-free interval in the whole series was 47.4 months for R <0.9 and 126.0 months for R ≥ 0.9 (p = 0.04). The survival time was 76.8 months for patients with R values <0.9 and 156.3 months for patients with R values ≥0.9 (p = 0.1). Conclusions: High serum levels of ganglioside sLe[sup x] significantly correlate with a favorable prognosis and with a lower occurrence of metastases. It is conceivable that soluble sLe[sup x] may compete with membrane-bound sLe[sup x] in the course of interactions between activated endothelium and tumor cells that have reached the circulation.Copyright © 2003 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
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| Items | – Name: Title Label: Title Group: Ti Data: Prognostic Role of Serum Sialyl Lewis[sup x] (CD15s) in Colorectal Cancer. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Paganuzzi%2C+Michela%22">Paganuzzi, Michela</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bobbio%2C+Barbara%22">Bobbio, Barbara</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Marroni%2C+Paola%22">Marroni, Paola</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Filiberti%2C+Rosa%22">Filiberti, Rosa</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Secco%2C+Giovanni+Battista%22">Secco, Giovanni Battista</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Grossi%2C+Carlo+Enrico%22">Grossi, Carlo Enrico</searchLink><relatesTo>4</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Oncology%22">Oncology</searchLink>. 2003, Vol. 65 Issue 1, p52-59. 8p. 2 Black and White Photographs, 2 Charts, 1 Graph. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22COLON+cancer%22">COLON cancer</searchLink><br />*<searchLink fieldCode="DE" term="%22GANGLIOSIDES%22">GANGLIOSIDES</searchLink><br />*<searchLink fieldCode="DE" term="%22CHROMATOGRAPHIC+analysis%22">CHROMATOGRAPHIC analysis</searchLink><br />*<searchLink fieldCode="DE" term="%22GLYCOPROTEINS%22">GLYCOPROTEINS</searchLink><br />*<searchLink fieldCode="DE" term="%22METASTASIS%22">METASTASIS</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective: Sialyl Lewis[sup x] (sLe[sup x] ) is one ligand for E selectin (CD62E), a glycoprotein that is expressed on activated endothelial cells. Adhesion mediated by endothelial E selectin and sLe[sup x] expressed on human tumor cells could be relevant for the development of metastases. The aim of this study was to investigate whether or not a correlation exists between pre-operative levels of ganglioside serum sLe[sup x] and disease-free interval and survival in colorectal cancer patients. Patients and Methods: Thirty Duke’s B and 52 Duke’s C patients undergoing resection for colorectal cancer were studied. The median follow-up time was 34.8 months. A pool of 57 sera from normal subjects was used as an Internal Normal Standard (INS). sLe[sup x] analyses were performed by a thin layer chromatography (TLC) immunostaining technique. Results were expressed as the ratio (R) between bands of INS and bands from each neoplastic serum. Results: The median R value was 0.80 in normal subjects, 0.70 in Duke’s B patients and 1.0 in Duke’s C patients. No significant differences were detected between sLe[sup x] concentrations in sera from normal and neoplastic subjects (p = 0.1). Using an arbitrary cutoff of R = 0.9, the mean disease-free interval in the whole series was 47.4 months for R <0.9 and 126.0 months for R ≥ 0.9 (p = 0.04). The survival time was 76.8 months for patients with R values <0.9 and 156.3 months for patients with R values ≥0.9 (p = 0.1). Conclusions: High serum levels of ganglioside sLe[sup x] significantly correlate with a favorable prognosis and with a lower occurrence of metastases. It is conceivable that soluble sLe[sup x] may compete with membrane-bound sLe[sup x] in the course of interactions between activated endothelium and tumor cells that have reached the circulation.Copyright © 2003 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Oncology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1159/000071205 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 52 Subjects: – SubjectFull: COLON cancer Type: general – SubjectFull: GANGLIOSIDES Type: general – SubjectFull: CHROMATOGRAPHIC analysis Type: general – SubjectFull: GLYCOPROTEINS Type: general – SubjectFull: METASTASIS Type: general Titles: – TitleFull: Prognostic Role of Serum Sialyl Lewis[sup x] (CD15s) in Colorectal Cancer. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Paganuzzi, Michela – PersonEntity: Name: NameFull: Bobbio, Barbara – PersonEntity: Name: NameFull: Marroni, Paola – PersonEntity: Name: NameFull: Filiberti, Rosa – PersonEntity: Name: NameFull: Secco, Giovanni Battista – PersonEntity: Name: NameFull: Grossi, Carlo Enrico IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2003 Type: published Y: 2003 Identifiers: – Type: issn-print Value: 00302414 Numbering: – Type: volume Value: 65 – Type: issue Value: 1 Titles: – TitleFull: Oncology Type: main |
| ResultId | 1 |