Bibliographic Details
| Title: |
Persistent Prelimbic Cortex Activity Contributes to Enhanced Learned Fear Expression in Females |
| Authors: |
Fenton, Georgina E., Pollard, Amelia K., Halliday, David M. |
| Source: |
Learning & Memory. Feb 2014 21(2):55-60. |
| Availability: |
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/ |
| Peer Reviewed: |
Y |
| Page Count: |
6 |
| Publication Date: |
2014 |
| Document Type: |
Journal Articles
Reports - Research |
| Descriptors: |
Anxiety Disorders, Fear, Females, Conditioning, Gender Differences, Animals, Cognitive Psychology |
| DOI: |
10.1101/lm.033514.113 |
| ISSN: |
1072-0502 |
| Abstract: |
Anxiety disorders, such as post-traumatic stress, are more prevalent in women and are characterized by impaired inhibition of learned fear and medial prefrontal cortex (mPFC) dysfunction. Here we examined sex differences in fear extinction and mPFC activity in rats. Females showed more learned fear expression during extinction and its recall, but not fear conditioning. They also showed more spontaneous fear recovery and more contextual fear before extinction and its recall. Moreover, enhanced learned fear expression in females was associated with sustained prelimbic (PL) cortex activity. These results suggest that sex differences in learned fear expression may involve persistent PL activation. |
| Abstractor: |
As Provided |
| Number of References: |
39 |
| Entry Date: |
2014 |
| Accession Number: |
EJ1027239 |
| Database: |
ERIC |
