Bibliographic Details
| Title: |
Methotrexate use, not interleukin 33, is associated with lower carotid intima-media thickness in patients with rheumatoid arthritis |
| Authors: |
Pinto, Maria Raquel Costa, Kakehasi, Adriana Maria, Souza, Adriano José, Tavares Jr, Wilson Campos, Rocha, Monaliza Angela, Trant, Cyntia Gabriele Michel Cardoso, Andrade, Marcus Vinicius |
| Source: |
Advances in Rheumatology. January 2019 59 |
| Publisher Information: |
Sociedade Brasileira de Reumatologia, 2019. |
| Publication Year: |
2019 |
| Subject Terms: |
Rheumatoid arthritis, Cardiovascular diseases, Interleukins, Methotrexate |
| More Details: |
Background: Rheumatoid arthritis is a risk factor for early mortality due to cardiovascular disease. Interleukin-33 appears to protect against the development of atherosclerosis. The purpose of this study was to investigate the relationship between serum levels of interleukin-33 and its soluble receptor with the presence of subclinical carotid atherosclerosis in rheumatoid arthritis patients. Methods: Rheumatoid arthritis patients without atherosclerotic disease were subjected to clinical and laboratory assessments, including carotid ultrasound. Interleukin-33 and its soluble receptor serum levels were measured by ELISA. Results: 102 patients were included. The prevalence of carotid plaques was 23.5% and the median intima-media thickness was 0.7 mm. The median interleukin-33 and its soluble receptor concentration was 69.1 and 469.8 pg/ml. No association was found between serum interleukin-33 or its soluble receptor and intima-media thickness or plaque occurrence. Each 0.1 mm increase of intima-media thickness raised the odds of plaque occurrence by 5.3-fold, and each additional year of rheumatoid arthritis duration increased the odds of plaque occurrence by 6%. Each additional year in patients age and each one-point increase in the Framingham Risk Score were associated with a 0.004 mm and 0.012 mm increase in intima-media thickness. Methotrexate use was associated with a 0.07 mm reduction in intima-media thickness. Conclusions: Interleukin-33 and its soluble receptor were not associated with subclinical atherosclerosis. Traditional risk factors for atherosclerosis and rheumatoid arthritis duration were associated with intima-media thickness and plaque occurrence; methotrexate use was associated with a lower intima-media thickness. |
| Document Type: |
article |
| File Description: |
text/html |
| Language: |
English |
| ISSN: |
2523-3106 |
| DOI: |
10.1186/s42358-019-0060-1 |
| Access URL: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2523-31062019000100210 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edssci.S2523.31062019000100210 |
| Database: |
SciELO |
