Bibliographic Details
| Title: |
Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil |
| Authors: |
Ribeiro, Jane Cristina Lara, Bruginski, Estevan, Zuccolotto, Tatiana, Santos, Alan Diego da Conceição, Bomfim, Larissa Mendes, Rocha, Suellen Laila Andrade, Barison, Andersson, Sassaki, Guilherme, Cavalcanti, Sócrates Cabral de Holanda, Costa, Emmanoel Vilaça, Soares, Milena Botelho Pereira, Bezerra, Daniel Pereira, Campos, Francinete Ramos |
| Source: |
Brazilian Journal of Pharmaceutical Sciences. January 2021 57 |
| Publisher Information: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, 2021. |
| Publication Year: |
2021 |
| Subject Terms: |
Annona salzmannii, Annonaceae, Larvicidal activity, Cytotoxic activity, Seed oil |
| More Details: |
The seed oil of Annona salzmannii A. DC. was analyzed by GC-MS and 1H qNMR, revealing a mixture of unsaturated (80.5%) and saturated (18.7%) fatty acids. Linoleic (45.3%) and oleic (33.5%) acid were the major unsaturated fatty acids identified, while palmitic acid (14.3%) was the major saturated fatty acid. The larvicidal effects of A. salzmannii seed oil were evaluated against third-instar larvae of Aedes aegypti (Linn.). The oil exhibited moderate larvicidal activity, with a LC50 of 569.77 ppm (95% CI = 408.11 to 825.88 ppm). However, when the cytotoxic effects of the oil were evaluated, no expressive antiproliferative effects were observed in tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia), HL-60 (human promyelocytic leukemia), and non-tumor cell line PBMC (peripheral blood mononuclear cells), with IC50 values > 50 μg·mL-1. This is the first study to evaluate the chemical composition, larvicidal and cytotoxic activity of A. salzmannii seed oil. |
| Document Type: |
article |
| File Description: |
text/html |
| Language: |
English |
| ISSN: |
1984-8250 |
| DOI: |
10.1590/s2175-97902020000418479 |
| Access URL: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502021000100510 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edssci.S1984.82502021000100510 |
| Database: |
SciELO |
