Bibliographic Details
| Title: |
Comparison of 7.2% hypertonic saline - 6% hydroxyethyl starch solution and 6% hydroxyethyl starch solution after the induction of anesthesia in patients undergoing elective neurosurgical procedures |
| Authors: |
Shao, Liujiazi, Wang, Baoguo, Wang, Shuangyan, Mu, Feng, Gu, Ke |
| Source: |
Clinics. January 2013 68(3) |
| Publisher Information: |
Faculdade de Medicina / USP, 2013. |
| Publication Year: |
2013 |
| Subject Terms: |
Hypertonic Saline, Hydroxyethyl Starch, Neurosurgery, Fluid Management |
| More Details: |
OBJECTIVE: The ideal solution for fluid management during neurosurgical procedures remains controversial. The aim of this study was to compare the effects of a 7.2% hypertonic saline - 6% hydroxyethyl starch (HS-HES) solution and a 6% hydroxyethyl starch (HES) solution on clinical, hemodynamic and laboratory variables during elective neurosurgical procedures. METHODS: Forty patients scheduled for elective neurosurgical procedures were randomly assigned to the HS-HES group orthe HES group. Afterthe induction of anesthesia, patients in the HS-HES group received 250 mL of HS-HES (500 mL/h), whereas the patients in the HES group received 1,000 mL of HES (1000 mL/h). The monitored variables included clinical, hemodynamic and laboratory parameters. Chictr.org: ChiCTR-TRC-12002357 RESULTS: The patients who received the HS-HES solution had a significant decrease in the intraoperative total fluid input (p<0.01), the volume of Ringer's solution required (p<0.05), the fluid balance (p<0.01) and their dural tension scores (p<0.05). The total urine output, blood loss, bleeding severity scores, operation duration and hemodynamic variables were similar in both groups (p>0.05). Moreover, compared with the HES group, the HS-HES group had significantly higher plasma concentrations of sodium and chloride, increasing the osmolality (p<0.01). CONCLUSION: Our results suggest that HS-HES reduced the volume of intraoperative fluid required to maintain the patients undergoing surgery and led to a decrease in the intraoperative fluid balance. Moreover, HS-HES improved the dural tension scores and provided satisfactory brain relaxation. Our results indicate that HS-HES may represent a new avenue for volume therapy during elective neurosurgical procedures. |
| Document Type: |
article |
| File Description: |
text/html |
| Language: |
English |
| ISSN: |
1807-5932 |
| DOI: |
10.6061/clinics/2013(03)OA07 |
| Access URL: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000300008 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edssci.S1807.59322013000300008 |
| Database: |
SciELO |
