Bibliographic Details
| Title: |
Insulin-like growth factor (IgF)-I, IgF binding protein-3, and prostate cancer: correlation with gleason score |
| Authors: |
Corrêa, Lívia L., Vieira Neto, Leonardo, Lima, Giovanna A. Balarini, Gabrich, Rafael, Miranda, Luiz Carlos D. de, Gadelha, Mônica R. |
| Source: |
International braz j urol. February 2015 41(1) |
| Publisher Information: |
Sociedade Brasileira de Urologia, 2015. |
| Publication Year: |
2015 |
| Subject Terms: |
Prostatic Neoplasms, Prostatic Hyperplasia, Insulin-Like Growth Factor I, Insulin-Like Growth Factor Binding Protein 3 |
| More Details: |
Introduction Non-androgenic growth factors are involved in the growth regulation of prostate cancer (PCa). Objective This is the first Brazilian study to correlate, in a population of patients operated for PCa, PSA, total testosterone, insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-3 (IGFBP-3) with Gleason score and to compare with a control group with benign prostate hyperplasia (BPH). Materials and Methods This retrospective single-center study included 49 men with previously diagnosed PCa and 45 with previously diagnosed BPH. PSA, testosterone, IGF-I, IGFBP-3 were determined in both groups. Results PSA and IGFBP-3 levels were significantly higher in the PCa group as compared to the BPH group (p<0.001 and p=0.004, respectively). There was a significant difference when we compared the PSA before surgery (p<0.001) and at the inclusion in the study (p<0.001) and IGFBP3 (0.016) among patients with Gleason <7, ≥7 and BPH. In the PCa group, PSA, testosterone, IGF-I and IGFBP-3 levels were comparable between Gleason <7 and ≥7. Conclusions Our data suggest that in localized PCa, the quantification of PSA and, not of IGF-1, may provide independent significant information in the aggressiveness. IGFBP-3 could be a biochemical marker of disease control in PCa patients. |
| Document Type: |
article |
| File Description: |
text/html |
| Language: |
English |
| ISSN: |
1677-5538 |
| DOI: |
10.1590/S1677-5538.IBJU.2015.01.15 |
| Access URL: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000100110 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edssci.S1677.55382015000100110 |
| Database: |
SciELO |
