Bibliographic Details
| Title: |
Are hemoglobin-derived peptides involved in the neuropsychiatric symptoms caused by SARS-CoV-2 infection? |
| Authors: |
Mendonça, Michelle Mendanha, da Cruz, Kellen Rosa, dos Santos Silva, Fernanda Cacilda, Fontes, Marco Antônio Peliky, Xavier, Carlos Henrique |
| Source: |
Brazilian Journal of Psychiatry. January 2022 |
| Publisher Information: |
Associação Brasileira de Psiquiatria, 2022. |
| Publication Year: |
2022 |
| Subject Terms: |
COVID-19, SARS-CoV-2, hemoglobin, neurotransmitters, hemorphins, hemopressins, neurology, psychiatry |
| More Details: |
Follow-up of patients affected by COVID-19 has unveiled remarkable findings. Among the several sequelae caused by SARS-CoV-2 viral infection, it is particularly noteworthy that patients are prone to developing depression, anxiety, cognitive disorders, and dementia as part of the post-COVID-19 syndrome. The multisystem aspects of this disease suggest that multiple mechanisms may converge towards post-infection clinical manifestations. The literature provides mechanistic hypotheses related to changes in classical neurotransmission evoked by SARS-CoV-2 infection; nonetheless, the interaction of peripherally originated classical and non-canonic peptidergic systems may play a putative role in this neuropathology. A wealth of robust findings shows that hemoglobin-derived peptides are able to control cognition, memory, anxiety, and depression through different mechanisms. Early erythrocytic death is found during COVID-19, which would cause excess production of hemoglobin-derived peptides. Following from this premise, the present review sheds light on a possible involvement of hemoglobin-derived molecules in the COVID-19 pathophysiology by fostering neuroscientific evidence that supports the contribution of this non-canonic peptidergic pathway. This rationale may broaden knowledge beyond the currently available data, motivating further studies in the field and paving ways for novel laboratory tests and clinical approaches. |
| Document Type: |
article |
| File Description: |
text/html |
| Language: |
English |
| ISSN: |
1516-4446 |
| DOI: |
10.47626/1516-4446-2021-2339 |
| Access URL: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022005007204 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edssci.S1516.44462022005007204 |
| Database: |
SciELO |
