Medication exposure and predictors of first mood episode in offspring of parents with bipolar disorder: a prospective study
| Title: | Medication exposure and predictors of first mood episode in offspring of parents with bipolar disorder: a prospective study |
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| Authors: | Nery, Fabiano G., Wilson, Anna R., Schneider, Marguerite R., Strawn, Jeffrey R., Patino, Luis R., McNamara, Robert K., Adler, Caleb M., Strakowski, Stephen M., DelBello, Melissa P. |
| Source: | Brazilian Journal of Psychiatry. October 2020 42(5) |
| Publisher Information: | Associação Brasileira de Psiquiatria, 2020. |
| Publication Year: | 2020 |
| Subject Terms: | Bipolar disorder, mood disorders, risk factors, antidepressive agents |
| More Details: | Objectives: To prospectively investigate whether baseline clinical characteristics and medication exposure predict development of major depressive disorder or bipolar disorder in offspring of parents with bipolar disorder. Methods: Youth aged 9-20 years with at least one biological parent with bipolar disorder and no prior history of mood or psychotic episodes (n=93) were prospectively evaluated and treated naturalistically during the study. Participants were divided into two groups: converters, defined as those who met DSM-IV criteria for a mood episode during follow-up (n=19); or non-converters (n=74). Logistic regression models were used to investigate associations between baseline clinical variables and medication exposure during follow-up and risk of developing a first mood episode (conversion). Results: Multivariate regression analyses showed that baseline anxiety disorders and subsyndromal mood disorders were associated with increased risk of conversion during follow-up. Adding medication exposure to the multivariate model showed that exposure to antidepressants during follow-up was associated with increased risk of conversion. Conclusions: Caution should be used when treating bipolar offspring with anxiety and/or emerging depressive symptoms using antidepressant agents, given the increased risk of developing a major mood disorder. |
| Document Type: | article |
| File Description: | text/html |
| Language: | English |
| ISSN: | 1516-4446 |
| DOI: | 10.1590/1516-4446-2019-0802 |
| Access URL: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462020000500481 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edssci.S1516.44462020000500481 |
| Database: | SciELO |
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