Bibliographic Details
| Title: |
Medication exposure and predictors of first mood episode in offspring of parents with bipolar disorder: a prospective study |
| Authors: |
Nery, Fabiano G., Wilson, Anna R., Schneider, Marguerite R., Strawn, Jeffrey R., Patino, Luis R., McNamara, Robert K., Adler, Caleb M., Strakowski, Stephen M., DelBello, Melissa P. |
| Source: |
Brazilian Journal of Psychiatry. October 2020 42(5) |
| Publisher Information: |
Associação Brasileira de Psiquiatria, 2020. |
| Publication Year: |
2020 |
| Subject Terms: |
Bipolar disorder, mood disorders, risk factors, antidepressive agents |
| More Details: |
Objectives: To prospectively investigate whether baseline clinical characteristics and medication exposure predict development of major depressive disorder or bipolar disorder in offspring of parents with bipolar disorder. Methods: Youth aged 9-20 years with at least one biological parent with bipolar disorder and no prior history of mood or psychotic episodes (n=93) were prospectively evaluated and treated naturalistically during the study. Participants were divided into two groups: converters, defined as those who met DSM-IV criteria for a mood episode during follow-up (n=19); or non-converters (n=74). Logistic regression models were used to investigate associations between baseline clinical variables and medication exposure during follow-up and risk of developing a first mood episode (conversion). Results: Multivariate regression analyses showed that baseline anxiety disorders and subsyndromal mood disorders were associated with increased risk of conversion during follow-up. Adding medication exposure to the multivariate model showed that exposure to antidepressants during follow-up was associated with increased risk of conversion. Conclusions: Caution should be used when treating bipolar offspring with anxiety and/or emerging depressive symptoms using antidepressant agents, given the increased risk of developing a major mood disorder. |
| Document Type: |
article |
| File Description: |
text/html |
| Language: |
English |
| ISSN: |
1516-4446 |
| DOI: |
10.1590/1516-4446-2019-0802 |
| Access URL: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462020000500481 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edssci.S1516.44462020000500481 |
| Database: |
SciELO |
