Efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trial

Bibliographic Details
Title: Efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for bipolar depression: study protocol for a proof-of-concept trial
Authors: Ashton, Melanie M., Berk, Michael, Ng, Chee H., Hopwood, Malcolm, Dodd, Seetal, Turner, Alyna, Brown, Ellie, Jacka, Felice N., Cotton, Susan M., Khoo, Jon-Paul, Chatterton, Mary Lou, Kavanagh, Bianca E., Nadjidai, Sarah E., Lo Monaco, Samantha L., Harvey, Brian H., Sarris, Jerome, Malhi, Gin S., Dowling, Nathan L., Dean, Olivia M.
Source: Brazilian Journal of Psychiatry. May 2019 41(3)
Publisher Information: Associação Brasileira de Psiquiatria, 2019.
Publication Year: 2019
Subject Terms: Garcinia mangostana, bipolar disorder, treatment, clinical trial, depression
More Details: Objective: Bipolar depression is characterized by neurobiological features including perturbed oxidative biology, reduction in antioxidant levels, and a concomitant rise in oxidative stress markers. Bipolar depression manifests systemic inflammation, mitochondrial dysfunction, and changes in brain growth factors. The depressive phase of the disorder is the most common and responds the least to conventional treatments. Garcinia mangostana Linn, commonly known as mangosteen, is a tropical fruit. The pericarp’s properties may reduce oxidative stress and inflammation and improve neurogenesis, making mangosteen pericarp a promising add-on therapy for bipolar depression. Methods: Participants will receive 24 weeks of either 1,000 mg mangosteen pericarp or placebo per day, in addition to their usual treatment. The primary outcome is change in severity of mood symptoms, measured using the Montgomery-Åsberg Depression Rating Scale (MADRS), over the treatment phase. Secondary outcomes include global psychopathology, quality of life, functioning, substance use, cognition, safety, biological data, and cost-effectiveness. A follow-up interview will be conducted 4 weeks post-treatment. Conclusion: The findings of this study may have implications for improving treatment outcomes for those with bipolar disorder and may contribute to our understanding of the pathophysiology of bipolar depression. Clinical trial registration: Australian and New Zealand Clinical Trial Registry, ACTRN12616000028404.
Document Type: article
File Description: text/html
Language: English
ISSN: 1516-4446
DOI: 10.1590/1516-4446-2018-0114
Access URL: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462019000300245
Rights: info:eu-repo/semantics/openAccess
Accession Number: edssci.S1516.44462019000300245
Database: SciELO
More Details
ISSN:15164446
DOI:10.1590/1516-4446-2018-0114
Published in:Brazilian Journal of Psychiatry
Language:English