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Retrospective analysis on efficacy of convalescent plasma in acute respiratory distress syndrome due to COVID-19

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Title: Retrospective analysis on efficacy of convalescent plasma in acute respiratory distress syndrome due to COVID-19
Authors: Eren, Esma, Ulu-Kılıç, Ayşegül, Korkmaz, Serdal, Yıldız, Merve, Yüksel, Recep Civan, Kılınç-Toker, Ayşin, Arman-Fırat, Emine, Bestepe-Dursun, Zehra, Çelik, Ilhami
Source: Sao Paulo Medical Journal. February 2022 140(1)
Publisher Information: Associação Paulista de Medicina - APM, 2022.
Publication Year: 2022
Subject Terms: COVID-19, Respiratory distress syndrome, COVID-19 serotherapy [supplementary concept], Coronavirus disease 2019, Convalescent plasma, Acute respiratory distress syndrome.
More Details: BACKGROUND: Coronavirus disease 2019 (COVID-19) is an ongoing global health threat. However, currently, no standard therapy has been approved for the disease. OBJECTIVES: To evaluate the clinical effectiveness of convalescent plasma (CP) in patients with acute respiratory distress syndrome (ARDS) due to COVID-19. DESIGN AND SETTING: Retrospective study conducted at Kayseri City Education and Research Hospital, Kayseri, Turkey. METHODS: The case group consisted of adult patients (> 18 years) with ARDS due to COVID-19 who received CP in combination with antiviral and supportive treatment. These patients were compared with others who only received antiviral and supportive treatment. RESULTS: During the study period, a total of 30 patients with ARDS due to COVID-19 were included. Eleven patients (36%) received CP in combination with antiviral and supportive treatment, whereas nineteen patients (64%) in the control group only received antiviral and supportive treatment. On admission, the median age, demographic and clinical data and initial laboratory test results were similar between the groups (P > 0.05). On the 14th day of treatment, the laboratory values remained similar between the groups (P > 0.05). The mortality rates were not significantly different between the groups. CONCLUSION: CP treatment did not affect mortality or lead to clinical improvement for COVID-19 patients with ARDS.
Document Type: article
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Language: English
ISSN: 1516-3180
DOI: 10.1590/1516-3180.2021.0200.r1.03052021
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  Data: Retrospective analysis on efficacy of convalescent plasma in acute respiratory distress syndrome due to COVID-19
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  Data: <searchLink fieldCode="AR" term="%22Eren%2C+Esma%22">Eren, Esma</searchLink><br /><searchLink fieldCode="AR" term="%22Ulu-Kılıç%2C+Ayşegül%22">Ulu-Kılıç, Ayşegül</searchLink><br /><searchLink fieldCode="AR" term="%22Korkmaz%2C+Serdal%22">Korkmaz, Serdal</searchLink><br /><searchLink fieldCode="AR" term="%22Yıldız%2C+Merve%22">Yıldız, Merve</searchLink><br /><searchLink fieldCode="AR" term="%22Yüksel%2C+Recep+Civan%22">Yüksel, Recep Civan</searchLink><br /><searchLink fieldCode="AR" term="%22Kılınç-Toker%2C+Ayşin%22">Kılınç-Toker, Ayşin</searchLink><br /><searchLink fieldCode="AR" term="%22Arman-Fırat%2C+Emine%22">Arman-Fırat, Emine</searchLink><br /><searchLink fieldCode="AR" term="%22Bestepe-Dursun%2C+Zehra%22">Bestepe-Dursun, Zehra</searchLink><br /><searchLink fieldCode="AR" term="%22Çelik%2C+Ilhami%22">Çelik, Ilhami</searchLink>
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  Data: <i>Sao Paulo Medical Journal</i>. February 2022 140(1)
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  Data: <searchLink fieldCode="DE" term="%22COVID-19%22">COVID-19</searchLink><br /><searchLink fieldCode="DE" term="%22Respiratory+distress+syndrome%22">Respiratory distress syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19+serotherapy+[supplementary+concept]%22">COVID-19 serotherapy [supplementary concept]</searchLink><br /><searchLink fieldCode="DE" term="%22Coronavirus+disease+2019%22">Coronavirus disease 2019</searchLink><br /><searchLink fieldCode="DE" term="%22Convalescent+plasma%22">Convalescent plasma</searchLink><br /><searchLink fieldCode="DE" term="%22Acute+respiratory+distress+syndrome%2E%22">Acute respiratory distress syndrome.</searchLink>
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  Data: BACKGROUND: Coronavirus disease 2019 (COVID-19) is an ongoing global health threat. However, currently, no standard therapy has been approved for the disease. OBJECTIVES: To evaluate the clinical effectiveness of convalescent plasma (CP) in patients with acute respiratory distress syndrome (ARDS) due to COVID-19. DESIGN AND SETTING: Retrospective study conducted at Kayseri City Education and Research Hospital, Kayseri, Turkey. METHODS: The case group consisted of adult patients (> 18 years) with ARDS due to COVID-19 who received CP in combination with antiviral and supportive treatment. These patients were compared with others who only received antiviral and supportive treatment. RESULTS: During the study period, a total of 30 patients with ARDS due to COVID-19 were included. Eleven patients (36%) received CP in combination with antiviral and supportive treatment, whereas nineteen patients (64%) in the control group only received antiviral and supportive treatment. On admission, the median age, demographic and clinical data and initial laboratory test results were similar between the groups (P > 0.05). On the 14th day of treatment, the laboratory values remained similar between the groups (P > 0.05). The mortality rates were not significantly different between the groups. CONCLUSION: CP treatment did not affect mortality or lead to clinical improvement for COVID-19 patients with ARDS.
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