| Title: |
The impact of visceral fat and levels of vitamin D on coronary artery calcification |
| Authors: |
Rodrigues, Isa Galvão, Pinho, Claudia Porto Sabino, Sobral Filho, Dário, Leão, Ana Paula Dornelas, Oliveira, Maria Cristina Monterio, Barbosa, Gerssica Pina, Siqueira, Aline Alves de, Bandeira, Francisco |
| Source: |
Revista da Associação Médica Brasileira. January 2021 67(1) |
| Publisher Information: |
Associação Médica Brasileira, 2021. |
| Publication Year: |
2021 |
| Subject Terms: |
Cardiovascular diseases, Vitamin D, Obesity, Vascular calcification |
| More Details: |
SUMMARY OBJECTIVE: To evaluated calcification of the coronary arteries and its association with visceral fat and 25-hydroxyvitamin D (25(OH)D) serum levels. METHODS: A cross sectional study involving 140 individuals without any previous diagnosis of cardiovascular disease. A biochemical analysis of vitamin D serum levels was carried out, as well as computed tomography to measure coronary artery calcium score and visceral adipose tissue. RESULTS: The mean age of the individuals was 55.9 (±12.4). Coronary artery calcium was observed in 40.7% of the population. Vitamin D presented median serum levels of 30.4 ng/ml (IQ24.5–39.1), with 14,1 and 33.7% of the individuals presenting deficiency and insufficiency, respectively. In the univariate analysis, the calcium score was more prevalent in aged patients (p<0.01), in hypertensive individuals (p<0.01), in diabetics (p=0.02), and in those with a higher concentration of VAT (p=0.02). In the adjusted analysis, it was found that the highest concentration of VAT (OR: 4.0; 95%CI 1.4–11.7), hypertension (OR: 4.8; 95%CI 1.5–15.3), and age (OR: 10.4; 95%CI 3.9–27.6) were predictors of subclinical atherosclerosis, regardless of body mass index, diabetes, and 25OHD. CONCLUSIONS: Excess visceral fat was associated with subclinical atherosclerosis, regardless of other risk factors for cardiovascular disease. Serum levels of 25OHD were not associated with CAD in its early stages. |
| Document Type: |
article |
| File Description: |
text/html |
| Language: |
English |
| ISSN: |
0104-4230 |
| DOI: |
10.1590/1806-9282.67.01.20200388 |
| Access URL: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302021000100088 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edssci.S0104.42302021000100088 |
| Database: |
SciELO |
