Bibliographic Details
| Title: |
Ultrasound-Promoted Synthesis of 3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides and Anticancer Activity Evaluation in Leukemia Cell Lines |
| Authors: |
Santos, Eric F. S. dos, Cury, Nathália M., Nascimento, Tainara A. do, Raminelli, Cristiano, Casagrande, Gleison A., Pereira, Claudio M. P., Simionatto, Euclésio, Yunes, José A., Pizzuti, Lucas |
| Source: |
Journal of the Brazilian Chemical Society. February 2017 28(2) |
| Publisher Information: |
Sociedade Brasileira de Química, 2017. |
| Publication Year: |
2017 |
| Subject Terms: |
amidinopyrazole, pyrazoline, cytotoxic activity, leukemia, ultrasonic irradiation |
| More Details: |
3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides were efficiently prepared through a cyclocondensation of thiophenylchalcones with aminoguanidine hydrochloride under ultrasonic conditions in the presence of KOH and ethanol as a green solvent in short reaction times (15-35 min) and good yields (62-95%). All compounds produced were evaluated against the human Jurkat and RS4;11 acute lymphoblastic leukemia cell lines of T- and B-cell origin, respectively, and the K562 myelogenous leukemia cell line. Six compounds presented half maximal inhibitory concentration (IC50) values around 15 µmol L-1 and five compounds presented IC50 values around 40 µmol L-1 for at least one of the three cell lines analyzed. One compound was not significantly cytotoxic, presenting IC50 value > 100 µmol L-1. |
| Document Type: |
article |
| File Description: |
text/html |
| Language: |
English |
| ISSN: |
0103-5053 |
| DOI: |
10.5935/0103-5053.20160166 |
| Access URL: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000200217 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edssci.S0103.50532017000200217 |
| Database: |
SciELO |
