Bibliographic Details
| Title: |
Inflammatory and oxidative stress after surgery for the small area corrections of burn sequelae |
| Authors: |
Vinha, Paula Pileggi, Jordão Jr, Alceu Afonso, Farina Jr, Jayme Adriano, Vannucchi, Helio, Marchini, Júlio Sérgio, Cunha, Selma Freire de Carvalho da |
| Source: |
Acta Cirúrgica Brasileira. August 2011 26(4) |
| Publisher Information: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2011. |
| Publication Year: |
2011 |
| Subject Terms: |
Oxidative Stress, Nutritional Status, Burns, Surgical Procedures, Operative |
| More Details: |
PURPOSE: To compare vitamin levels, inflammatory and oxidative stress markers before and after skin autograft surgery to correct burn scar areas. METHODS: This prospective study was conducted with 8 patients with a median age of 28 years (range, 16 to 40 years) that had burn sequelae and were admitted to a Burn Unit for correction of small burn scar areas [3.3 (1.0-5.0) % of the corporal surface]. The volunteers were evaluated before and 48 hours after excision of scar tissue and skin autograft. Routine laboratory data, along with a food questionnaire and anthropometry were collected in the preoperative period. Serum vitamin A, C, E, B12 and folic acid levels, inflammatory markers (C-protein reactive, alpha-1-acid glycoprotein, ferritin) and oxidative stress markers (reduced glutathione - GSH and Thiobarbituric Acid Reactive Substances - TBARS) were determined at preoperative and postoperative phases. Data were analyzed with two-sample Wilcoxon test. RESULTS: All volunteers were clinically stable and had adequate nutritional status at admission. After surgery, C-reactive protein serum levels increased [0.4 (0.01-1.0) vs. 2.5 (0.6-4.7) mg/dL, p=0.01] and vitamin A levels decreased [3.4 (2.1-4.2) vs. 2.4 (1.6-4.1) µmol/L, p=0.01]. No changes occurred in other vitamins, ferrritin, alpha-1-acid glycoprotein, GSH and TBARS levels. CONCLUSION: Minimal metabolic changes were produced after skin autograft in small areas of well-nourished patients without active infection or inflammation. |
| Document Type: |
article |
| File Description: |
text/html |
| Language: |
English |
| ISSN: |
0102-8650 |
| DOI: |
10.1590/S0102-86502011000400013 |
| Access URL: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000400013 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edssci.S0102.86502011000400013 |
| Database: |
SciELO |
