Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia

Bibliographic Details
Title: Allium sativum Compared to Cilostazol as an Inhibitor of Myointimal Hyperplasia
Authors: Lima, Paulo Roberto da Silva, Bandeira, Francisco Chavier Vieira, Rolim, Janio Cipriano, Nogueira, Manuel Ricardo Sena, Pordeus, Mizael Armando Abrantes, Oliveira, Andressa Feitosa Bezerra de, Pitta, Guilherme Benjamin Brandão
Source: Brazilian Journal of Cardiovascular Surgery. September 2016 31(4)
Publisher Information: Sociedade Brasileira de Cirurgia Cardiovascular, 2016.
Publication Year: 2016
Subject Terms: Hyperplasia, Garlic, Rabbits
More Details: Objective: Intimal hyperplasia is associated with graft failure and vascular sutures in the first year after surgery and in postangioplasty restenosis. Allium sativum (common garlic) lowers cholesterol and has antioxidant effects; it also has antiplatelet and antitumor properties and, therefore, has great potential to reduce or inhibit intimal hyperplasia of the arteries. Our objective is to determine if the garlic has an efficacy to inhibit myointimal hyperplasia compared to cilostazol. Methods: Female New Zealand rabbits were divided into the following groups (n=10 each) according to treatment: group A, garlic, 800 µg×kg-1×day-1, orally; group C, cilostazol, 50 mg.day-1, orally; group PS, 10 ml of 0.9% physiological saline solution, orally. Our primary is the difference of the mean of myointimal hyperplasia. Statistical analysis was performed by using ANOVA and Tukey tests, as well as the Chi-square test. We calculated the 95% confidence interval for each point estimate, and the P value was set as < 0.05. Results: Group PS had a mean hyperplasia rate of 35.74% (95% CI, 31.76–39.71%); group C, 16.21% (95% CI, 13.36–19.05%); and group A, 21.12% (95% CI, 17.26–25.01%); P<0.0001. Conclusion: We conclude that Allium sativum had the same efficacy in inhibiting myointimal hyperplasia when compared to the positive control, cilostazol.
Document Type: article
File Description: text/html
Language: English
ISSN: 0102-7638
DOI: 10.5935/1678-9741.20160069
Access URL: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382016000400291
Rights: info:eu-repo/semantics/openAccess
Accession Number: edssci.S0102.76382016000400291
Database: SciELO
More Details
ISSN:01027638
DOI:10.5935/1678-9741.20160069
Published in:Brazilian Journal of Cardiovascular Surgery
Language:English