Bibliographic Details
| Title: |
CTLA4 enhances the osteogenic differentiation of allogeneic human mesenchymal stem cells in a model of immune activation |
| Authors: |
Dai, F., Zhang, F., Sun, D., Zhang, Z.H., Dong, S.W., Xu, J.Z. |
| Source: |
Brazilian Journal of Medical and Biological Research. July 2015 48(7) |
| Publisher Information: |
Associação Brasileira de Divulgação Científica, 2015. |
| Publication Year: |
2015 |
| Subject Terms: |
CTLA4, Mesenchymal stem cells, Immunomodulatory, Bone tissue engineering |
| More Details: |
Allogeneic mesenchymal stem cells (allo-MSCs) have recently garnered increasing interest for their broad clinical therapy applications. Despite this, many studies have shown that allo-MSCs are associated with a high rate of graft rejection unless immunosuppressive therapy is administered to control allo-immune responses. Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) is a co-inhibitory molecule expressed on T cells that mediates the inhibition of T-cell function. Here, we investigated the osteogenic differentiation potency of allo-MSCs in an activated immune system that mimics the in vivo allo-MSC grafting microenvironment and explored the immunomodulatory role of the helper T cell receptor CTLA4 in this process. We found that MSC osteogenic differentiation was inhibited in the presence of the activated immune response and that overexpression of CTLA4 in allo-MSCs suppressed the immune response and promoted osteogenic differentiation. Our results support the application of CTLA4-overexpressing allo-MSCs in bone tissue engineering. |
| Document Type: |
article |
| File Description: |
text/html |
| Language: |
English |
| ISSN: |
0100-879X |
| DOI: |
10.1590/1414-431x20154209 |
| Access URL: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000700629 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edssci.S0100.879X2015000700629 |
| Database: |
SciELO |
