Bibliographic Details
| Title: |
Constituintes químicos das cascas do caule de Vochysia thyrsoidea Pohl. (Vochysiaceae) e avaliação das atividades citotóxica e inibitória frente as catepsinas B e K |
| Authors: |
Sousa, Lorena Ramos Freitas de, Silva, Jame's A. da, Vieira, Paulo Cezar, Costa, Maísa Borges, Santos, Mirley Luciene dos, Sbardelotto, Aline Borba, Pessoa, Cláudia do Ó, Moraes, Manoel Odorico de, Menezes, Antônio Carlos Severo |
| Source: |
Química Nova. April 2014 37(2) |
| Publisher Information: |
Sociedade Brasileira de Química, 2014. |
| Publication Year: |
2014 |
| Subject Terms: |
Vochysia thyrsoidea, Vochysiaceae, catechin derivatives |
| More Details: |
A new flavonoid, catechin-3-O-(3"-O-trans-cinnamoyl)-α-rhamnopyranoside, along with known compounds, catechin-3-O-α-rhamnopyranoside, 3-oxo-urs-12-en-28-oic acid, 2,4,6-trimethoxybenzoic acid, 2-butyl-D-fructofuranoside and 1-butyl-D-fructofuranoside, has been isolated from the stem bark of V. thyrsoidea. These compounds were assayed for inhibition of protease activity (cathepsins B and K) and against cancer cell lines. Catechin-3-O-(3"-O-trans-cinnamoyl)-α-rhamnopyranoside showed moderate inhibitory activity (IC50 = 62.02 µM) against cathepsin B while 2-butyl-D-fructofuranoside was the most potent against a strain of CNS (SF-295) and human leukemia (HL-60) with IC50 = 36.80 µM and IC50 = 25.37 µM, respectively. |
| Document Type: |
article |
| File Description: |
text/html |
| Language: |
Portuguese |
| ISSN: |
0100-4042 |
| DOI: |
10.5935/0100-4042.20140049 |
| Access URL: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000200016 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edssci.S0100.40422014000200016 |
| Database: |
SciELO |
