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Whole-genome sequencing of a Plasmodium vivax isolate from the China-Myanmar border area

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Title: Whole-genome sequencing of a Plasmodium vivax isolate from the China-Myanmar border area
Authors: Shen, Hai-Mo, Chen, Shen-Bo, Wang, Yue, Chen, Jun-Hu
Source: Memórias do Instituto Oswaldo Cruz. September 2015 110(6)
Publisher Information: Instituto Oswaldo Cruz, Ministério da Saúde, 2015.
Publication Year: 2015
Subject Terms: Plasmodium vivax, genome, vir
More Details: Currently, there is a trend of an increasing number of Plasmodium vivaxmalaria cases in China that are imported across its Southeast Asia border, especially in the China-Myanmar border area (CMB). To date, little is known about the genetic diversity of P. vivaxin this region. In this paper, we report the first genome sequencing of a P. vivaxisolate (CMB-1) from a vivax malaria patient in CMB. The sequencing data were aligned onto 96.43% of the P. vivaxSalvador I reference strain (Sal I) genome with 7.84-fold coverage as well as onto 98.32% of 14 Sal I chromosomes. Using the de novoassembly approach, we generated 8,541 scaffolds and assembled a total of 27.1 Mb of sequence into CMB-1 scaffolds. Furthermore, we identified all 295 known virgenes, which is the largest subtelomeric multigene family in malaria parasites. These results provide an important foundation for further research onP. vivaxpopulation genetics.
Document Type: article
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Language: English
ISSN: 0074-0276
DOI: 10.1590/0074-02760150216
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  Data: Whole-genome sequencing of a Plasmodium vivax isolate from the China-Myanmar border area
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  Data: <searchLink fieldCode="AR" term="%22Shen%2C+Hai-Mo%22">Shen, Hai-Mo</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Shen-Bo%22">Chen, Shen-Bo</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Yue%22">Wang, Yue</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Jun-Hu%22">Chen, Jun-Hu</searchLink>
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  Data: <i>Memórias do Instituto Oswaldo Cruz</i>. September 2015 110(6)
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  Data: Instituto Oswaldo Cruz, Ministério da Saúde, 2015.
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  Data: Currently, there is a trend of an increasing number of Plasmodium vivaxmalaria cases in China that are imported across its Southeast Asia border, especially in the China-Myanmar border area (CMB). To date, little is known about the genetic diversity of P. vivaxin this region. In this paper, we report the first genome sequencing of a P. vivaxisolate (CMB-1) from a vivax malaria patient in CMB. The sequencing data were aligned onto 96.43% of the P. vivaxSalvador I reference strain (Sal I) genome with 7.84-fold coverage as well as onto 98.32% of 14 Sal I chromosomes. Using the de novoassembly approach, we generated 8,541 scaffolds and assembled a total of 27.1 Mb of sequence into CMB-1 scaffolds. Furthermore, we identified all 295 known virgenes, which is the largest subtelomeric multigene family in malaria parasites. These results provide an important foundation for further research onP. vivaxpopulation genetics.
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