Bibliographic Details
| Title: |
Whole-genome sequencing of a Plasmodium vivax isolate from the China-Myanmar border area |
| Authors: |
Shen, Hai-Mo, Chen, Shen-Bo, Wang, Yue, Chen, Jun-Hu |
| Source: |
Memórias do Instituto Oswaldo Cruz. September 2015 110(6) |
| Publisher Information: |
Instituto Oswaldo Cruz, Ministério da Saúde, 2015. |
| Publication Year: |
2015 |
| Subject Terms: |
Plasmodium vivax, genome, vir |
| More Details: |
Currently, there is a trend of an increasing number of Plasmodium vivaxmalaria cases in China that are imported across its Southeast Asia border, especially in the China-Myanmar border area (CMB). To date, little is known about the genetic diversity of P. vivaxin this region. In this paper, we report the first genome sequencing of a P. vivaxisolate (CMB-1) from a vivax malaria patient in CMB. The sequencing data were aligned onto 96.43% of the P. vivaxSalvador I reference strain (Sal I) genome with 7.84-fold coverage as well as onto 98.32% of 14 Sal I chromosomes. Using the de novoassembly approach, we generated 8,541 scaffolds and assembled a total of 27.1 Mb of sequence into CMB-1 scaffolds. Furthermore, we identified all 295 known virgenes, which is the largest subtelomeric multigene family in malaria parasites. These results provide an important foundation for further research onP. vivaxpopulation genetics. |
| Document Type: |
article |
| File Description: |
text/html |
| Language: |
English |
| ISSN: |
0074-0276 |
| DOI: |
10.1590/0074-02760150216 |
| Access URL: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000600814 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edssci.S0074.02762015000600814 |
| Database: |
SciELO |
