Bibliographic Details
| Title: |
Lingual salivary gland hypertrophy and decreased acinar density in chagasic patients without megaesophagus |
| Authors: |
Bertoldo, Bárbara Bellocchio, Etchebehere, Renata Margarida, Furtado, Taíssa Cássia de Souza, Faria, Juliana Barbosa de, Silva, Camilla Beatriz, Araújo, Márcia Fernandes de, Rodrigues, Denise Bertulucci Rocha, Pereira, Sanivia Aparecida de Lima |
| Source: |
Revista do Instituto de Medicina Tropical de São Paulo. January 2019 61 |
| Publisher Information: |
Instituto de Medicina Tropical de São Paulo, 2019. |
| Publication Year: |
2019 |
| Subject Terms: |
Acinar density, Chagas disease, Megaesophagus, Morphometry, Salivary glands, Tongue |
| More Details: |
Although the salivary glands present several functions, there are few studies evaluating these glands in Chagas disease (CD). This study aimed to compare the percentage of collagen, the presence of inflammation, the density of chimase and tryptase mast cells, the area and density of lingual salivary gland acini in autopsied individuals with and without (CD). We analyzed 400 autopsy reports performed in a tertiary public hospital from 1999 to 2015 and selected all the cases in which tongue fragments were collected (27 cases), 12 with chronic CD without megaesophagus (CH) and 15 without CD (non-chagasic - NC). The histological sections of the tongue were stained by Picrosirius red for collagen evaluation and Hematoxylin-eosin for morphometric evaluation of salivary gland acini and inflammation. Anti-chimase and anti-tryptase antibodies were used for the immunohistochemical evaluation of mast cells. The chagasic patients presented higher volume and lower density of salivary glands acini. There was no difference in the collagen percentage, inflammation and density of mast cell chymase and tryptase between the groups. Although we did not observe a significant difference between the groups regarding the collagen percentage, inflammatory process and mast cell density, our results suggest that even without megaesophagus, chagasic patients present hypertrophy of the lingual salivary glands and lower acinar density probably due to mechanisms independent of the esophagus-glandular stimulus. |
| Document Type: |
article |
| File Description: |
text/html |
| Language: |
English |
| ISSN: |
0036-4665 |
| DOI: |
10.1590/s1678-9946201961067 |
| Access URL: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652019005000237 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edssci.S0036.46652019005000237 |
| Database: |
SciELO |
