Bibliographic Details
| Title: |
Binswanger's disease and quantitative fractional anisotropy |
| Authors: |
Engelhardt, Eliasz, Moreira, Denise Madeira, Alves, Gilberto Sousa, Lanna, Maria Elisa Oliveira, Alves, Carlos Eduardo de Oliveira, Ericeira-Valente, Letice, Sudo, Felipe Kenji, Laks, Jerson |
| Source: |
Arquivos de Neuro-Psiquiatria. June 2009 67(2a) |
| Publisher Information: |
Academia Brasileira de Neurologia - ABNEURO, 2009. |
| Publication Year: |
2009 |
| Subject Terms: |
Binswanger's disease, white matter, leukoaraiosis, diffusion tensor, fractional anisotropy |
| More Details: |
OBJECTIVE: To study the integrity of the white matter in Binswanger's disease (BD) patients with quantitative fractional anisotropy (DTI-FA). METHOD: Controls (12) and patients with BD (12) were included. Scans performed with MR (GE Signa Horizon/1.5T). Fazekas's score=6 with white matter hyperintensities extension >75% assessed on FLAIR scans. Standard parameters for DTI-FA were used. ROIs placed in symmetrical regions on two axial planes, data pooled in anterior (frontal) and posterior (temporo-parieto-occipital) regions. Analysis with Functool. Statistics for anterior and posterior regions comparison. RESULTS: DTI-FA showed reduction of anisotropy, reflecting axonal damage and demyelination of fibers, more prominent in anterior in relation to posterior region, in BD patients in comparison to controls. CONCLUSION: Loss of integrity of fiber tracts reflects interruption of neural networks that subserve cognitive, behavioral, and motor integration. The more severely affected frontal region is related to executive dysfunction, a characteristic feature of Binswanger's disease. |
| Document Type: |
article |
| File Description: |
text/html |
| Language: |
English |
| ISSN: |
0004-282X |
| DOI: |
10.1590/S0004-282X2009000200002 |
| Access URL: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2009000200002 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edssci.S0004.282X2009000200002 |
| Database: |
SciELO |
