| Title: |
Osteoporosis management in patient with renal function impairment |
| Authors: |
Lima, Guilherme Alcantara Cunha, Paranhos Neto, Francisco de Paula, Pereira, Giselly Rosa Modesto, Gomes, Carlos Perez, Farias, Maria Lucia Fleiuss |
| Source: |
Arquivos Brasileiros de Endocrinologia & Metabologia. July 2014 58(5) |
| Publisher Information: |
Sociedade Brasileira de Endocrinologia e Metabologia, 2014. |
| Publication Year: |
2014 |
| Subject Terms: |
Bone quality, CKD-MBD, DXA, fractures, osteoporosis |
| More Details: |
Aging is associated with decreases in bone quality and in glomerular filtration. Consequently, osteoporosis and chronic kidney disease (CKD) are common comorbid conditions in the elderly, and often coexist. Biochemical abnormalities in the homeostasis of calcium and phosphorus begin early in CKD, leading to an increase in fracture risk and cardiovascular complications since early stages of the disease. The ability of DXA (dual energy X-ray absorptiometry) to diagnose osteoporosis and to predict fractures in this population remains unclear. The management of the disease is also controversial: calcium and vitamin D, although recommended, must be prescribed with caution, considering vascular calcification risk and the development of adynamic bone disease. Furthermore, safety and effectiveness of osteoporosis drugs are not established in patients with CKD. Thus, risks and benefits of antiosteoporosis treatment must be considered individually. |
| Document Type: |
article |
| File Description: |
text/html |
| Language: |
English |
| ISSN: |
0004-2730 |
| DOI: |
10.1590/0004-2730000003360 |
| Access URL: |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000500530 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edssci.S0004.27302014000500530 |
| Database: |
SciELO |
