Extracellular/epidermal growth factor like protein
| Title: | Extracellular/epidermal growth factor like protein |
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| Patent Number: | 7,393,832 |
| Publication Date: | July 01, 2008 |
| Appl. No: | 11/017065 |
| Application Filed: | December 21, 2004 |
| Abstract: | The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of DNA synthesis, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention. |
| Inventors: | Olsen, Henrik S. (Gaithersburg, MD, US); Li, Haodong (Gaithersburg, MD, US) |
| Assignees: | Human Genome Sciences, Inc. (Rockville, MD, US) |
| Claim: | 1. An isolated protein selected from the group consisting of: (a) an isolated protein comprising amino acid residues 1 to 448 of SEQ ID NO:2; (b) an isolated protein comprising amino acid residues 2 to 448 of SEQ ID NO:2; and (c) an isolated protein comprising amino acid residues 26 to 448 of SEQ ID NO:2. |
| Claim: | 2. The isolated protein of claim 1 , wherein said protein is (a). |
| Claim: | 3. The isolated protein of claim 1 , wherein said protein is (b). |
| Claim: | 4. The isolated protein of claim 1 , wherein said protein is (c). |
| Claim: | 5. The isolated protein of claim 1 , which further comprises a heterologous polypeptide. |
| Claim: | 6. A composition comprising the isolated protein of claim 1 and a pharmaceutically acceptable carrier. |
| Claim: | 7. An isolated protein produced by a method comprising: (a) expressing the protein of claim 1 by a cell; and (b) recovering the protein of claim 1 . |
| Current U.S. Class: | 514/12 |
| Patent References Cited: | 4845075 July 1989 Murray et al. |
| Other References: | Campbell et al. Epidermal growth factor-like modules. Curr Opin Struct Biol. 1993, 3:385-392. cited by examiner Appella et al. Structure and function of epidermal growth factor like regions in proteins. FEBS Lett. Apr. 11, 1988;231(1):1-4. cited by examiner Brandt et al. Identification and biological characterization of an epidermal growth factor related protein: cripto 1. J Biol Chem. Jun. 24, 1994;269(25):17320-8. cited by examiner Bowie et al. Deciphering the message in protein sequences: tolerance to amino acid substitutions. Science, (Mar. 16, 1990) 247 (4948) 1306-10. cited by examiner Ngo et al., in The Protein Folding Problem and Tertiary Structure Prediction, Merz and Le Grand (Eds), Aug. 1994, Springer Verlag, pp. 433 and 492-495. cited by examiner |
| Primary Examiner: | Romeo, David S |
| Accession Number: | edspgr.07393832 |
| Database: | USPTO Patent Grants |
| Language: | English |
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