Compound useful for the treatment of neuropathic pain
| Title: | Compound useful for the treatment of neuropathic pain |
|---|---|
| Patent Number: | 7,220,775 |
| Publication Date: | May 22, 2007 |
| Appl. No: | 10/637299 |
| Application Filed: | August 07, 2003 |
| Abstract: | This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor and are useful for the treatment of neuropathic pain and other abnormalities. This invention also provides a method of treating a subject suffering from an abnormality which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's abnormality. This invention also provides a method of treating an abnormality in a subject which comprises administering to the subject a composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a GAL3 receptor antagonist. |
| Inventors: | Blackburn, Thomas P. (Hoboken, NJ, US) |
| Assignees: | H. Lundbeck A/S (Copenhagen-Valby, DK) |
| Claim: | 1. A method of treating a subject suffering from neuropathic pain, which comprises administering to the subject an amount of a compound effective to treat the subject's neuropathic pain, wherein the compound has the structure: [chemical expression included] or a pharmaceutically acceptable salt thereof [chemical expression included] |
| Current U.S. Class: | 514/416 |
| Patent References Cited: | 5576296 November 1996 Bartfai et al. 6511827 January 2003 Howard et al. 7081470 July 2006 Konkel et al. 514361 November 1992 667340 August 1995 WO9212997 August 1992 WO9815570 April 1998 WO9931130 June 1999 WO0002865 January 2000 WO0260392 August 2002 |
| Other References: | U.S. Appl. No. 10/638,242, filed May 2004, Konkel et al. cited by examiner U.S. Appl. No. 10/723,961, filed Jul. 2004, Blackburn et al. cited by examiner U.S. Appl. No. 11/298,116, filed Dec. 2005, Blackburn et al. cited by examiner U.S. Appl. No. 11/343,810, filed Jan. 2006, Konkel et al. cited by examiner U.S. Appl. No. 11/343,989, filed Jan. 2006, Konkel et al. cited by examiner Swanson, C. J. et al. “Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299” (2005) PNAS vol. 102, No. 48, pp. 17489-17494. cited by examiner Liu, H. X. et al. “Effect of intrathecal galanin and its putative antagonist M35 on pain begavior in a neuropathic pain model” (2000) Brain Research vol. 886, pp. 67-72. cited by examiner Silverman, Richard B. The Organic Chemistry of Drug Design and Drug Action, (1992) Published by Academic Press, pp. 65-71. cited by examiner Ahmad, A., et al., “Identification And Molecular Cloning Of ANovel Galanin Receptor (GALR-2) In Rat Sensory Neurons”, Soc.Neurosci. Abstr. (1996) 22(3): 1682, Abstract No. 661.10 (Exhibit 10). cited by other Ahmad, S., et al., “Molecular Cloning Of A Novel Widely Distributed Galanin Receptor Subtype (GALR2),” International Association for the Study of Pain (IASP Press)(1996) Abstract No. 81: 134 (Exhibit 11). cited by other Ahmad, S. Et al., Astra Pain Control (1996), poster (Exhibit 12). cited by other Bartfai, T., et al, “Galanin Receptor Ligand M40 Peptide Distinguishes Between Putative Galanin- Receptor Subtypes,” PNAS (USA)(1993) 90: 11287-11291 (Exhibit 13). cited by other Branchek, et al., “Galanin Receptor Subtypes,” Trends In Pharmacological Sciences. Elsevier Trends Journal. 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| Assistant Examiner: | Olson, Eric S. |
| Primary Examiner: | Jiang, Shaojia Anna |
| Attorney, Agent or Firm: | Kalinchak, Stephen G. |
| Accession Number: | edspgr.07220775 |
| Database: | USPTO Patent Grants |
| Language: | English |
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