Process for producing alanylglutamine
| Title: | Process for producing alanylglutamine |
|---|---|
| Patent Number: | 5,550,283 |
| Publication Date: | August 27, 1996 |
| Appl. No: | 08/307,417 |
| Application Filed: | September 19, 1994 |
| Abstract: | Disclosed is a process for producing alanylglutamine, which comprises reacting an N-(2-substituted)-propionylglutamine compound represented by the formula (I): ##STR1## where X represents halogen, alkylsulfonyloxy, or substituted or unsubstituted arylsulfonyloxy, with ammonia at a temperature of 60.degree. C. or below. in accordance with the present invention, highly purified alanylglutamine can be produced in a high yield, without racemization. |
| Inventors: | Inoue, Kunimi (Sakai, JPX); Yamada, Yoshiyuki (Sakai, JPX); Amatsu, Kazumi (Sakai, JPX); Mimura, Yukiteru (Shizuoka-ken, JPX); Nakaguchi, Yasunori (Sakai, JPX); Shinmura, Hiroyuki (Sakai, JPX); Ono, Yasuyuki (Isehara, JPX); Osawa, Yutaka (Ichikawa, JPX); Mizutaki, Shoichi (Kawachinagano, JPX); Kasai, Masaji (Fujisawa, JPX); Tomioka, Shinji (Hashimoto, JPX) |
| Assignees: | Kyowa Hakko Kogyo Co., Ltd. (Tokyo, JPX) |
| Claim: | What is claimed is |
| Claim: | 1. N-(2-substituted)propionylglutamine compound represented by the formula ##STR8## ##STR9## or a salt thereof. |
| Claim: | 2. A compound according to claim 1, which is N-(2-D-chloro)propionyl-L-glutamine. |
| Current U.S. Class: | 562/561 |
| Current International Class: | C07C22900 |
| Other References: | Shimonishi et al., Bull. Chem. Soc. J., vol. 35 (1962) 1966-70. Shimonishi et al., Bull. Chem. Soc. J., vol. 37 (1964) 200-3. Akabori et al., Bull. Chem. Soc. J., vol. 34 (1961) 739. Thierfelder et al., Hoppe-Seyler's Z. Phys. Chem., vol. 105 (1919) 58-82. Chemical Abstracts, vol. 99, No. 1 (1983) 6016a. Y. Ogata et al., Bull. Chem. Soc. Jpn., vol. 54, No. 11 (1981) 3605-06. Mar., Advanced Organic Chemistry, 4th Edition (1992) 411-413. Greenstein, Chemistry of the Amino Acids, vol. 1 (1961) 700-703; 712-714; vol. 2 (1961) 808-816; 1272-1295. |
| Primary Examiner: | Shippen, Michael L. |
| Attorney, Agent or Firm: | Fitzpatrick, Cella, Harper & Scinto |
| Accession Number: | edspgr.05550283 |
| Database: | USPTO Patent Grants |
| Language: | English |
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