| Title: |
Oligopeptides And Cosmetic Compositions Containing The Oligopeptides |
| Document Number: |
20120129784 |
| Publication Date: |
May 24, 2012 |
| Appl. No: |
13/328684 |
| Application Filed: |
December 16, 2011 |
| Abstract: |
Oligopeptides according to formula (I) and/or (II), R1-Tyr-Pro-Trp-Phe-NH2 (I, SEQ ID NO:1); R1-Tyr-Pro-PhePhe-NH2 (II, SEQ ID NO:2), wherein R1 is linked to the NH2-group of the amino-terminal part of Tyr and is selected from the group consisting of —H; a linear saturated or unsaturated or branched saturated or unsaturated acyl group having 1 to 24 carbon atoms, which may be functionalized by a —OH, —SH, —COOH or —CONH+ group; a sterol or a sphingolipid group which is linked to the amino terminal part of Tyr via a bifunctional linker are disclosed. Cosmetic compositions containing the oligopeptides are also disclosed. |
| Inventors: |
Gillon, Véronique (Essey-les-Nancy, FR); Moussou, Philippe (Tomblaine, FR); Contet-Audonneau, Jean-Luc (Saint-Max, FR); Freis, Olga (Seichamps, FR) |
| Assignees: |
Cognis IP Management GmbH (Dusseldorf, DE) |
| Claim: |
1. A method for reducing skin discomfort and/or pain due to an irritating cosmetic agent in a cosmetic composition comprising administering to skin in need thereof a cosmetic composition which comprises a) an oligopeptide according to formula (I) and/or (II): [table included] wherein R1 is linked to the NH2-group of the amino-terminal portion of Tyr and is selected from the group consisting of: (i) —H; (ii) a linear saturated or unsaturated or branched saturated or unsaturated acyl group having 1 to 24 carbon atoms, which acyl group can be functionalized by a —OH, —SH, —COOH or —CONH2 group; and (iii) a sterol or a sphingolipid group which is linked to the amino terminal portion of Tyr by a bifunctional linker; b) an irritating cosmetic agent; and c) optionally, an additive or auxiliary suitable for use in a cosmetic composition; wherein the oligopeptide is present in the composition in an amount sufficient to reduce discomfort and/or pain due to the irritating cosmetic agent when the cosmetic composition is administered cutaneously. |
| Claim: |
2. The method of claim 1, wherein the oligopeptide has a sequence N-Acetyl-Tyr-Pro-Trp-Phe-NH2 (SEQ ID NO:3) or N-Acetyl-Tyr-Pro-Phe-Phe-NH2 (SEQ ID NO:4. |
| Claim: |
3. The method of claim 1, wherein the oligopeptide is present in an amount of from about 0.001 to 1,000 ppm based by weight of the composition. |
| Claim: |
4. The method of claim 3, wherein the oligopeptide is present in an amount of about 0.05 to 500 ppm. |
| Claim: |
5. The method of claim 4, wherein the oligopeptide is present in an amount of about 0.5 to 100 ppm. |
| Claim: |
6. The method of claim 1, wherein the composition is administered to reduce thermal sensitivity of the skin. |
| Claim: |
7. The method of claim 1, wherein the composition is administered to prevent symptoms of skin discomfort and/or pain due to an irritating cosmetic agent. |
| Claim: |
8. The method of claim 1, wherein the composition is administered to ameliorate existing symptoms of skin discomfort and/or pain due to an irritating cosmetic agent. |
| Claim: |
9. The method of claim 1, wherein the composition is administered to sensitive skin. |
| Claim: |
10. The method of claim 1 wherein the irritating cosmetic agent is an alpha-hydroxy or beta-hydroxy acid or a salt or ester thereof. |
| Claim: |
11. The method of claim 10, wherein the alpha-hydroxy acid is selected from C2 to C12 alpha-hydroxy acids and esters thereof with a C2 to C24 alcohol. |
| Claim: |
12. The method of claim 10, wherein the beta-hydroxy acid is selected from C2 to C12 beta-hydroxy acids and esters thereof with a C2 to C24 alcohol. |
| Claim: |
13. The method of claim 10, wherein the acid is selected from the group consisting of lactic acid, citric acid, glycolic acid, gentisic acid, salicylic acid, gluconic acid and heptonic acid. |
| Claim: |
14. The method of claim 1 wherein the irritating cosmetic agent is a retinoid. |
| Claim: |
15. The method of claim 14, wherein the retinoid is selected from the group consisting of retinol, retinal, retinoic acid, retinyl acetate, retinyl palmitate and retinyl ascorbate. |
| Claim: |
16. A cosmetic composition which comprises: a) an oligopeptide according to formula (I) and/or (II) of: [table included] wherein R1 is linked to the NH2-group of the amino-terminal portion of Tyr and is selected from the group consisting of: (i) —H; (ii) a linear saturated or unsaturated or branched saturated or unsaturated acyl group having 1 to 24 carbon atoms, which acyl group can be functionalized by a —OH, —SH, —COOH or —CONH2 group; and (iii) a sterol or a sphingolipid group which is linked to the amino terminal portion of Tyr by a bifunctional linker. b) an irritating cosmetic agent; and c) optionally, an additive or auxiliary suitable for use in a cosmetic composition; wherein the oligopeptide is present in the composition in an amount sufficient to reduce discomfort and/or pain due to the irritating cosmetic agent when the cosmetic composition is administered cutaneously. |
| Claim: |
17. The cosmetic composition of claim 16, wherein the oligopeptide has a sequence N-Acetyl-Tyr-Pro-Trp-Phe-NH2 (SEQ ID NO:3) or N-Acetyl-Tyr-Pro-Phe-Phe-NH2 (SEQ ID NO:4. |
| Claim: |
18. The cosmetic composition of claim 16, wherein the irritating cosmetic agent is an alpha-hydroxy or beta-hydroxy acid or a salt or ester thereof. |
| Claim: |
19. The cosmetic composition of claim 16, wherein the irritating cosmetic agent is a retinoid. |
| Claim: |
20. The cosmetic composition of claim 16, wherein the oligopeptides is present in an amount of from about 0.5 to 100 ppm. |
| Current U.S. Class: |
514/183 |
| Current International Class: |
61; 61; 61 |
| Accession Number: |
edspap.20120129784 |
| Database: |
USPTO Patent Applications |
