Bibliographic Details
| Title: |
MODERATING THE EFFECT OF ENDOTOXINS |
| Document Number: |
20100028316 |
| Publication Date: |
February 4, 2010 |
| Appl. No: |
12/483861 |
| Application Filed: |
June 12, 2009 |
| Abstract: |
The present invention relates to the use of an oral composition comprising yeast extract, in the manufacture of an oral composition to treat the effects of infection by pathogenic bacteria such as Clostridium difficile. Such effects may include the failure of the integrity of the gut epithelial cells and diarrhoea as well as other COX-2 mediated effects. |
| Inventors: |
Corthesy-Theulaz, Irène (Epalinges, CH); Fotopoulos, Grigorios (Romont, CH); Bergonzelli, Gabriela (Bussigny-Pres Lausanne, CH) |
| Assignees: |
Nestec S.A. (Vevey, CH) |
| Claim: |
1-9. (canceled) |
| Claim: |
10. A method for manufacturing an oral composition to treat the effects of infection caused by enterotoxin-producing pathogens, the method comprising: adding 0.01% to 0.5% yeast extract by volume to an oral composition. |
| Claim: |
11. The method of claim 10 wherein the effects include failure of gut epithelial integrity, diarrhea and other COX-2 mediated effects. |
| Claim: |
12. The method of claim 10 wherein the pathogen is selected from the group consisting of Clostridium difficile, Clostridium perfringens, E. coli Leishmania donovani, Vibrio cholera, Salmonella typhimurium, Shingellae, Aeromonas hydrophila, Staphylococcus aureus, and enterotoxigenic Bacteroides fragilis. |
| Claim: |
13. The method of claim 10 wherein the oral composition comprises peptones. |
| Claim: |
14. The method of claim 10 wherein the peptones are hydrolysates of whey protein with an average peptide size of not greater than 5 amino acids. |
| Claim: |
15. The method of claim 10 wherein the oral composition further comprises meat extract. |
| Claim: |
16. The method of claim 10 wherein the oral composition is an adjuvant to a medicinal treatment. |
| Claim: |
17. The method of claim 10 wherein the oral composition is selected from the group consisting of an infant formula and an enteral composition. |
| Claim: |
18. The method of claim 13 wherein the peptones are present in an amount of from 0.3 to 7% by volume. |
| Claim: |
19. The method of claim 15 wherein the meat extract is present in an amount of from 0.3 to 7% by volume. |
| Current U.S. Class: |
424/9/351 |
| Current International Class: |
61 |
| Accession Number: |
edspap.20100028316 |
| Database: |
USPTO Patent Applications |
