| Title: |
Thermosensitive nanostructure for hyperthermia treatment |
| Document Number: |
20070154397 |
| Publication Date: |
July 5, 2007 |
| Appl. No: |
11/511464 |
| Application Filed: |
August 29, 2006 |
| Abstract: |
A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of about 40-45° C. The thermosensitive polymer nanostructure may carry a drug. When the magnetic nanoparticles are heated to 40-45° C. by application of an alternating magnetic field in hyperthermia treatment, the thermosensitive polymer nanostructure collapses to release the drug, thus providing concurrent drug treatment. |
| Inventors: |
Chang, Wen Hsiang (Taipei City, TW); Kao, Chao-Hung (Taipei, TW); Lin, Chin-I (Tainan County, TW); Wang, Shian-Jy (Hsinchu County, TW) |
| Claim: |
1. A thermosensitive nanostructure for hyperthermia treatment, comprising a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of about 40-45° C.; and magnetic nanoparticles encapsulated in the thermosensitive polymer nanostructure. |
| Claim: |
2. The thermosensitive nanostructure as claimed in claim 1, wherein the thermosensitive polymer nanostructure comprises diblock copolymer, triblock copolymer, or latex. |
| Claim: |
3. The thermosensitive nanostructure as claimed in claim 1, wherein the thermosensitive polymer nanostructure comprises thermosensitive polymer nanoparticles. |
| Claim: |
4. The thermosensitive nanostructure as claimed in claim 1, wherein the thermosensitive polymer nanostructure comprises a micelle composed of copolymers having critical micelle concentration (CMC) behavior. |
| Claim: |
5. The thermosensitive nanostructure as claimed in claim 1, wherein the thermosensitive polymer nanostructure has a diameter between about 10 and 300 nm. |
| Claim: |
6. The thermosensitive nanostructure as claimed in claim 1, wherein the thermosensitive polymer nanostructure is provided with hydroxyl, amine, or carboxyl groups. |
| Claim: |
7. The thermosensitive nanostructure as claimed in claim 1, wherein the thermosensitive polymer nanostructure is grafted with a ligand. |
| Claim: |
8. The thermosensitive nanostructure as claimed in claim 1, further comprising a drug encapsulated in the thermosensitive polymer nanostructure, wherein the drug is released during hyperthermia treatment. |
| Claim: |
9. The thermosensitive nanostructure as claimed in claim 1, further comprising a NO donor encapsulated in the thermosensitive polymer nanostructure. |
| Claim: |
10. The thermosensitive nanostructure as claimed in claim 1, wherein the magnetic nanoparticles are contrast agents for magnetic resonance imaging (MRI). |
| Claim: |
11. The thermosensitive nanostructure as claimed in claim 1, wherein the thermosensitive polymer nanostructure increases r2 value of the magnetic nanoparticles. |
| Claim: |
12. The thermosensitive nanostructure as claimed in claim 1, wherein the thermosensitive polymer nanostructure increases specific absorption rate (SAR) of the magnetic nanoparticles. |
| Claim: |
13. The thermosensitive nanostructure as claimed in claim 1, wherein the thermosensitive polymer nanostructure has a lower critical solution temperature (LCST) of about 42-45° C. |
| Current U.S. Class: |
424/934 |
| Current International Class: |
61 |
| Accession Number: |
edspap.20070154397 |
| Database: |
USPTO Patent Applications |
