| Title: |
Block copolymers and nano micelles comprising the same |
| Document Number: |
20070154396 |
| Publication Date: |
July 5, 2007 |
| Appl. No: |
11/448015 |
| Application Filed: |
June 07, 2006 |
| Abstract: |
A block copolymer. The block copolymer has formula A-B-C, wherein A represents polyester, B represents polyamide, and C represents specific molecular groups or metal complexes. The invention also provides a nano micelle and drug carrier including the block copolymer. |
| Inventors: |
Wang, Chau-Hui (Kaohsiung City, TW); Hsiue, Ging-Ho (Hsinchu, TW); Lin, Chin-I (Tainan County, TW); Wang, Shian-Jy Jassy (Hsinchu County, TW) |
| Claim: |
1. A block copolymer having formula A-B-C, wherein A comprises polyester, B comprises polyamide, and C comprises specific molecular groups or metal complexes. |
| Claim: |
2. The block copolymer as claimed in claim 1, wherein the block copolymer comprises diblock copolymer. |
| Claim: |
3. The block copolymer as claimed in claim 1, wherein the polyester comprises polylactide (PLA) or derivatives thereof. |
| Claim: |
4. The block copolymer as claimed in claim 1, wherein the polyamide comprises polyoxazoline (POz) or derivatives thereof. |
| Claim: |
5. The block copolymer as claimed in claim 1, wherein the specific molecular group recognizes cancer cells. |
| Claim: |
6. The block copolymer as claimed in claim 1, wherein the specific molecular group comprises folate. |
| Claim: |
7. The block copolymer as claimed in claim 6, wherein the block copolymer has formula (I) [chemical expression included] wherein L comprises hydrogen or C1-6 alkyl, Z comprises hydrogen, C2-21 acyl, or C2-21 benzyl, Q comprises initiators for ring-opening polymerization, G comprises acyl or ester groups, and x and y are 1˜10,000. |
| Claim: |
8. The block copolymer as claimed in claim 7, wherein the initiator for ring-opening polymerization comprises hydrogen, alkyl, or hydroxyl groups. |
| Claim: |
9. The block copolymer as claimed in claim 7, wherein y/x is 0.1˜1,000. |
| Claim: |
10. The block copolymer as claimed in claim 1, wherein the specific molecular group comprises antibody. |
| Claim: |
11. The block copolymer as claimed in claim 1, wherein the metal complex comprises magnetic resonance imaging (MRI) contrast agents. |
| Claim: |
12. The block copolymer as claimed in claim 11, wherein the MRI contrast agent comprises chelates formed by diethylenetriaminepentaacetic acid (DTPA) and gadolinium ions (Gd3+) or indium (111In). |
| Claim: |
13. The block copolymer as claimed in claim 12, wherein the chelate formed by diethylenetriaminepentaacetic acid (DTPA) and gadolinium ions (Gd3+) or indium (111In) has a chelating ratio of about 1˜100 wt %. |
| Claim: |
14. The block copolymer as claimed in claim 12, wherein the block copolymer has formula (II) [chemical expression included] wherein D comprises hydrogen or C1-6 alkyl, E comprises hydrogen, C2-21 acyl, or C2-21 benzyl, Q comprises initiators for ring-opening polymerization, G comprises acyl or ester groups, and a and b are 1˜10,000. |
| Claim: |
15. The block copolymer as claimed in claim 14, wherein the initiator for ring-opening polymerization comprises hydrogen, alkyl, or hydroxyl groups. |
| Claim: |
16. The block copolymer as claimed in claim 14, wherein b/a is 0.1˜1,000. |
| Claim: |
17. A nano micelle comprising a plurality of block copolymers as claimed in claim 1 or a plurality of block copolymers comprising specific molecular groups and metal complexes. |
| Claim: |
18. The nano micelle as claimed in claim 17, wherein the nano micelle has a hydrophobic interior and hydrophilic exterior. |
| Claim: |
19. The nano micelle as claimed in claim 17, wherein the nano micelle has a diameter of about 10˜1,000 nm. |
| Claim: |
20. The nano micelle as claimed in claim 17, wherein the nano micelle has a diameter of about 20˜200 nm. |
| Claim: |
21. The nano micelle as claimed in claim 17, wherein the nano micelle has critical micelle concentration (CMC) of about 0.0001˜1 mg/mL. |
| Claim: |
22. The nano micelle as claimed in claim 17, wherein the nano micelle has a relaxivity of about 5.0˜6.0(mM·s)−. |
| Claim: |
23. A nano drug carrier, comprising: a nano micelle as claimed in claim 17; and a drug encapsulated thereinto. |
| Claim: |
24. The nano drug carrier as claimed in claim 23, wherein the drug comprises water-insoluble drugs. |
| Claim: |
25. The nano drug carrier as claimed in claim 23, wherein the drug comprises camptothecin, doxorubicin, or derivatives thereof. |
| Claim: |
26. The nano drug carrier as claimed in claim 23, wherein the nano drug carrier is delivered by oral, transdermal administration, injection, or inhalation. |
| Current U.S. Class: |
424/934 |
| Current International Class: |
61; 61; 07 |
| Accession Number: |
edspap.20070154396 |
| Database: |
USPTO Patent Applications |
