Vector genome loss and epigenetic modifications mediate decline in transgene expression of AAV5 vectors produced in mammalian and insect cells

Bibliographic Details
Title: Vector genome loss and epigenetic modifications mediate decline in transgene expression of AAV5 vectors produced in mammalian and insect cells
Authors: Handyside, Britta, Ismail, Ashrafali Mohamed, Zhang, Lening, Yates, Bridget, Xie, Lin, Sihn, Choong-Ryoul, Murphy, Ryan, Bouwman, Taren, Kim, Chan Kyu, De Angelis, Rolando, Karim, Omair A., McIntosh, Nicole L., Doss, Michael Xavier, Shroff, Shilpa, Pungor, Erno, Bhat, Vikas S., Bullens, Sherry, Bunting, Stuart, Fong, Sylvia
Source: In Molecular Therapy 7 December 2022 30(12):3570-3586
Database: ScienceDirect
More Details
ISSN:15250016
DOI:10.1016/j.ymthe.2022.11.001
Published in:Molecular Therapy
Language:English