Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease

Bibliographic Details
Title: Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease
Authors: Chen, Jian Jeffrey, Liu, Qingyian, Yuan, Chester, Gore, Vijay, Lopez, Patricia, Ma, Vu, Amegadzie, Albert, Qian, Wenyuan, Judd, Ted C., Minatti, Ana E., Brown, James, Cheng, Yuan, Xue, May, Zhong, Wenge, Dineen, Thomas A., Epstein, Oleg, Human, Jason, Kreiman, Charles, Marx, Isaac, Weiss, Matthew M., Hitchcock, Stephen A., Powers, Timothy S., Chen, Kui, Wen, Paul H., Whittington, Douglas A., Cheng, Alan C., Bartberger, Michael D., Hickman, Dean, Werner, Jonathan A., Vargas, Hugo M., Everds, Nancy E., Vonderfecht, Steven L., Dunn, Robert T., II, Wood, Stephen, Fremeau, Robert T., Jr., White, Ryan D., Patel, Vinod F.
Source: In Bioorganic & Medicinal Chemistry Letters 15 February 2015 25(4):767-774
Database: ScienceDirect
More Details
ISSN:0960894X
DOI:10.1016/j.bmcl.2014.12.092
Published in:Bioorganic & Medicinal Chemistry Letters
Language:English