Bibliographic Details
| Title: |
Efficacy, safety, and tolerability of three regimens for prevention of malaria: a randomized, placebo-controlled trial in Ugandan schoolchildren. |
| Authors: |
Joaniter Nankabirwa, Bonnie Cundill, Sian Clarke, Narcis Kabatereine, Philip J Rosenthal, Grant Dorsey, Simon Brooker, Sarah G Staedke |
| Source: |
PLoS ONE, Vol 5, Iss 10, p e13438 (2010) |
| Publisher Information: |
Public Library of Science (PLoS), 2010. |
| Publication Year: |
2010 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
Intermittent preventive treatment (IPT) is a promising malaria control strategy; however, the optimal regimen remains unclear. We conducted a randomized, single-blinded, placebo-controlled trial to evaluate the efficacy, safety, and tolerability of a single course of sulfadoxine-pyrimethamine (SP), amodiaquine + SP (AQ+SP) or dihydroartemisinin-piperaquine (DP) among schoolchildren to inform IPT.Asymptomatic girls aged 8 to 12 years and boys aged 8 to 14 years enrolled in two primary schools in Tororo, Uganda were randomized to receive one of the study regimens or placebo, regardless of presence of parasitemia at enrollment, and followed for 42 days. The primary outcome was risk of parasitemia at 42 days. Survival analysis was used to assess differences between regimens.Of 780 enrolled participants, 769 (98.6%) completed follow-up and were assigned a treatment outcome. The risk of parasitemia at 42 days varied significantly between DP (11.7% [95% confidence interval (CI): 7.9, 17.1]), AQ+SP (44.3% [37.6, 51.5]), and SP (79.7% [95% CI: 73.6, 85.2], p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC2957410?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0013438 |
| Access URL: |
https://doaj.org/article/fffc16667b54431cbec00d18ffa8fc0b |
| Accession Number: |
edsdoj.fffc16667b54431cbec00d18ffa8fc0b |
| Database: |
Directory of Open Access Journals |
