Bibliographic Details
| Title: |
LncRNA and mRNA expression profiles in brown adipose tissue of obesity-prone and obesity-resistant mice |
| Authors: |
Congcong Wang, Meng Duan, Jinhua Lin, Guowei Wang, He Gao, Mengsha Yan, Lin Chen, Jialing He, Wei Liu, Fei Yang, Shankuan Zhu |
| Source: |
iScience, Vol 25, Iss 8, Pp 104809- (2022) |
| Publisher Information: |
Elsevier, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Science |
| Subject Terms: |
Physiology, Omics, Transcriptomics, Science |
| More Details: |
Summary: Obesity-prone or obesity-resistant phenotypes can exist in individuals who consume the same diet type. Brown adipose tissue functions to dissipate energy in response to cold exposure or overfeeding. Long noncoding RNAs play important roles in a wide range of biological processes. However, systematic examination of lncRNAs in phenotypically divergent mice has not yet been reported. Here, the lncRNA expression profiles in BAT of HFD-induced C57BL/6J mice were investigated by high-throughput RNA sequencing. Genes that play roles in thermogenesis and related pathways were identified. We found lncRNA (Gm44502) may play a thermogenic role in obesity resistance by interacting with six mRNAs. Our results also indicated that seven differentially expressed lncRNAs (4930528G23Rik, Gm39490, Gm5627, Gm15551, Gm16083, Gm36860, Gm42002) may play roles in reducing heat production in obesity susceptibility by interacting with seven differentially expressed mRNAs. The screened lncRNAs may participate in the pathogenesis of weight regulation and provide insight into obesity therapy. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004222010811; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2022.104809 |
| Access URL: |
https://doaj.org/article/afff3965be8f4c3c834346bb2e5ce67e |
| Accession Number: |
edsdoj.fff3965be8f4c3c834346bb2e5ce67e |
| Database: |
Directory of Open Access Journals |
