Transmission Dynamics of Highly Pathogenic Avian Influenza Virus A(H5Nx) Clade 2.3.4.4, North America, 2014–2015
| Title: | Transmission Dynamics of Highly Pathogenic Avian Influenza Virus A(H5Nx) Clade 2.3.4.4, North America, 2014–2015 |
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| Authors: | Dong-Hun Lee, Mia Kim Torchetti, Joseph Hicks, Mary Lea Killian, Justin Bahl, Mary Pantin-Jackwood, David E. Swayne |
| Source: | Emerging Infectious Diseases, Vol 24, Iss 10, Pp 1840-1848 (2018) |
| Publisher Information: | Centers for Disease Control and Prevention, 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Medicine LCC:Infectious and parasitic diseases |
| Subject Terms: | highly pathogenic avian influenza, avian influenza, transmission, epidemiology, Eurasian H5, clade 2.3.4.4, Medicine, Infectious and parasitic diseases, RC109-216 |
| More Details: | Eurasia highly pathogenic avian influenza virus (HPAIV) H5 clade 2.3.4.4 emerged in North America at the end of 2014 and caused outbreaks affecting >50 million poultry in the United States before eradication in June 2015. We investigated the underlying ecologic and epidemiologic processes associated with this viral spread by performing a comparative genomic study using 268 full-length genome sequences and data from outbreak investigations. Reassortant HPAIV H5N2 circulated in wild birds along the Pacific flyway before several spillover events transmitting the virus to poultry farms. Our analysis suggests that >3 separate introductions of HPAIV H5N2 into Midwest states occurred during March–June 2015; transmission to Midwest poultry farms from Pacific wild birds occurred ≈1.7–2.4 months before detection. Once established in poultry, the virus rapidly spread between turkey and chicken farms in neighboring states. Enhanced biosecurity is required to prevent the introduction and dissemination of HPAIV across the poultry industry. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/24/10/17-1891_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid2410.171891 |
| Access URL: | https://doaj.org/article/cff52d0b719c486f9dec3ea9715e2425 |
| Accession Number: | edsdoj.ff52d0b719c486f9dec3ea9715e2425 |
| Database: | Directory of Open Access Journals |
| ISSN: | 10806040 10806059 |
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| DOI: | 10.3201/eid2410.171891 |
| Published in: | Emerging Infectious Diseases |
| Language: | English |