Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome
| Title: | Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome |
|---|---|
| Authors: | Leonardo Mancabelli, Christian Milani, Federico Fontana, Gabriele Andrea Lugli, Chiara Tarracchini, Francesca Turroni, Douwe van Sinderen, Marco Ventura |
| Source: | Journal of Oral Microbiology, Vol 14, Iss 1 (2022) |
| Publisher Information: | Taylor & Francis Group, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Infectious and parasitic diseases LCC:Microbiology |
| Subject Terms: | Human respiratory tract, oral microbiota, pulmonary, microbiome, shotgun metagenomics, sputum, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502 |
| More Details: | Background The Human Respiratory Tract (HRT) is colonized by various microbial taxa, known as HRT microbiota, in a manner that is indicative of mutualistic interaction between such microorganisms and their host.Aim To investigate the microbial composition of the HRT and its possible correlation with the different compartments of the respiratory tract.Methods In the current study, we performed an in-depth meta‐analysis of 849 HRT samples from public shotgun metagenomic datasets obtained through several distinct collection methods.Results The statistical robustness provided by this meta-analysis allowed the identification of 13 possible HRT-specific Community State Types (CSTs), which appear to be specific to each anatomical region of the respiratory tract. Furthermore, functional characterization of the metagenomic datasets revealed specific microbial metabolic features correlating with the different compartments of the respiratory tract.Conclusion The meta-analysis here performed suggested that the variable presence of certain bacterial species seems to be linked to a location-related abundance gradient in the HRT and seems to be characterized by a specific microbial metabolic capability. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 20002297 2000-2297 |
| Relation: | https://doaj.org/toc/2000-2297 |
| DOI: | 10.1080/20002297.2022.2051336 |
| Access URL: | https://doaj.org/article/ff50409bd2984742a1856ef527170350 |
| Accession Number: | edsdoj.ff50409bd2984742a1856ef527170350 |
| Database: | Directory of Open Access Journals |
| ISSN: | 20002297 |
|---|---|
| DOI: | 10.1080/20002297.2022.2051336 |
| Published in: | Journal of Oral Microbiology |
| Language: | English |