Academic Journal
Relatively rapid evolution rates of SARS-CoV-2 spike gene at the primary stage of massive vaccination
| Title: | Relatively rapid evolution rates of SARS-CoV-2 spike gene at the primary stage of massive vaccination |
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| Authors: | Jing Yang, Min Han, Liang Wang, Likui Wang, Tianrui Xu, Linhuan Wu, Juncai Ma, Gary Wong, Wenjun Liu, George F. Gao, Yuhai Bi |
| Source: | Biosafety and Health, Vol 4, Iss 4, Pp 228-233 (2022) |
| Publisher Information: | Elsevier, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Infectious and parasitic diseases LCC:Public aspects of medicine |
| Subject Terms: | SARS-CoV-2, Vaccine, Genetic evolution, Genetic drift, Antigenic drift, Lineage divergence, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270 |
| More Details: | A series of stringent non-pharmacological and pharmacological interventions were implemented to contain the pandemic but the pandemic continues. Moreover, vaccination breakthrough infection and reinfection in convalescent coronavirus disease 2019 (COVID-19) cases have been reported. Further, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants emerged with mutations in spike (S) gene, the target of most current vaccines. Importantly, the mutations exhibit a trend of immune escape from the vaccination. Herein the scientific question that if the vaccination drives genetic or antigenic drifts of SARS-CoV-2 remains elusive. We performed correlation analyses to uncover the impacts of wide vaccination on epidemiological characteristics of COVID-19. In addition, we investigated the evolutionary dynamics and genetic diversity of SARS-CoV-2 under immune pressure by utilizing the Bayesian phylodynamic inferences and the lineage entropy calculation respectively. We found that vaccination coverage was negatively related to the infections, severe cases, and deaths of COVID-19 respectively. With the increasing vaccination coverage, the lineage diversity of SARS-CoV-2 dampened, but the rapid mutation rates of the S gene were identified, and the vaccination could be one of the explanations for driving mutations in S gene. Moreover, new epidemics resurged in several countries with high vaccination coverage, questioning their current pandemic control strategies. Hence, integrated vaccination and non-pharmacological interventions are critical to control the pandemic. Furthermore, novel vaccine preparation should enhance its capabilities to curb both disease severity and infection possibility. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2590-0536 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2590053622000799; https://doaj.org/toc/2590-0536 |
| DOI: | 10.1016/j.bsheal.2022.07.001 |
| Access URL: | https://doaj.org/article/fee598f533304454b63343968b341968 |
| Accession Number: | edsdoj.fee598f533304454b63343968b341968 |
| Database: | Directory of Open Access Journals |
| ISSN: | 25900536 |
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| DOI: | 10.1016/j.bsheal.2022.07.001 |
| Published in: | Biosafety and Health |
| Language: | English |