Mitochondrial Fusion/Fission, Transport and Autophagy in Parkinson's Disease: When Mitochondria Get Nasty

Bibliographic Details
Title: Mitochondrial Fusion/Fission, Transport and Autophagy in Parkinson's Disease: When Mitochondria Get Nasty
Authors: Daniela M. Arduíno, A. Raquel Esteves, Sandra M. Cardoso
Source: Parkinson's Disease, Vol 2011 (2011)
Publisher Information: Hindawi Limited, 2011.
Publication Year: 2011
Collection: LCC:Neurology. Diseases of the nervous system
Subject Terms: Neurology. Diseases of the nervous system, RC346-429
More Details: Understanding the molecular basis of Parkinson's disease (PD) has proven to be a major challenge in the field of neurodegenerative diseases. Although several hypotheses have been proposed to explain the molecular mechanisms underlying the pathogenesis of PD, a growing body of evidence has highlighted the role of mitochondrial dysfunction and the disruption of the mechanisms of mitochondrial dynamics in PD and other parkinsonian disorders. In this paper, we comment on the recent advances in how changes in the mitochondrial function and mitochondrial dynamics (fusion/fission, transport, and clearance) contribute to neurodegeneration, specifically focusing on PD. We also evaluate the current controversies in those issues and discuss the role of fusion/fission dynamics in the mitochondrial lifecycle and maintenance. We propose that cellular demise and neurodegeneration in PD are due to the interplay between mitochondrial dysfunction, mitochondrial trafficking disruption, and impaired autophagic clearance.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2042-0080
Relation: https://doaj.org/toc/2042-0080
DOI: 10.4061/2011/767230
Access URL: https://doaj.org/article/feb070f21aae4663b1bc3719b50a4c4f
Accession Number: edsdoj.feb070f21aae4663b1bc3719b50a4c4f
Database: Directory of Open Access Journals
More Details
ISSN:20420080
DOI:10.4061/2011/767230
Published in:Parkinson's Disease
Language:English